Initiating RNA Polymerase II and TIPs as hallmarks of enhancer activity and tissue-specificity

In recent years, many efforts were invested to define epigenetic features associated with enhancers of transcription. We propose that both transcription initiation and the H3K4me3 histone modification are among the best hallmarks of active enhancers in several primary tissues and extend the concept...

Full description

Saved in:
Bibliographic Details
Published in:Transcription 2011-11, Vol.2 (6), p.263-268
Main Authors: Koch, Frederic, Andrau, Jean-Christophe
Format: Article
Language:English
Subjects:
Animals
Binding
Biochemistry, Molecular Biology
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Enhancer Elements, Genetic - genetics
Gene Expression Profiling
Histones - metabolism
Humans
Landes
Life Sciences
Lysine - metabolism
Methylation
Organogenesis
Point-of-View
Promoter Regions, Genetic - genetics
Protein Binding
Proteins
RNA Polymerase II - metabolism
Transcription Factors - metabolism
Transcription, Genetic - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In recent years, many efforts were invested to define epigenetic features associated with enhancers of transcription. We propose that both transcription initiation and the H3K4me3 histone modification are among the best hallmarks of active enhancers in several primary tissues and extend the concept of large transcription initiation platforms (TIPs).
ISSN:2154-1264
2154-1272
DOI:10.4161/trns.2.6.18747