The Urinary Excretory Ratio of Nicotinamide Catabolites Was Associated with the Conversion Ratio of Tryptophan to Nicotinamide in Growing Rats Fed a Niacin-Free 20% Casein Diet

Weaning rats were fed a niacin-free 20% casein diet. Twenty-four-h-urine samples were collected, and nicotinamide and its catabolites were measured. A correlation was found between the urinary excretory ratio of nicotinamide catabolites (N 1 -methyl-2-pyridone-5-carboxamide + N 1 -methyl-4-pyridone-...

Full description

Saved in:
Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2012-01, Vol.76 (1), p.186-188
Main Authors: SHIBATA, Katsumi, IMAI, Eri, SANO, Mitsue, FUKUWATARI, Tsutomu
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Caseins - chemistry
Diet
Fundamental and applied biological sciences. Psychology
Male
methyl-2-pyridone-5-carboxamide
methyl-4-pyridone-3-carboxamide
methylnicotinamide
Niacin
Niacinamide - metabolism
Niacinamide - urine
Rats
Rats, Wistar
Time Factors
Tryptophan - metabolism
tryptophan-nicotinamide conversion ratio
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Weaning rats were fed a niacin-free 20% casein diet. Twenty-four-h-urine samples were collected, and nicotinamide and its catabolites were measured. A correlation was found between the urinary excretory ratio of nicotinamide catabolites (N 1 -methyl-2-pyridone-5-carboxamide + N 1 -methyl-4-pyridone-3-carboxamide)/N 1 -methylnicotinamide and the tryptophan-nicotinamide conversion ratio during growing period of the rats. This indicates the possibility that the conversion ratio can be deduced from the excretory ratio.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.110564