Poly(methyl methacrylate) particulate carriers in drug delivery

Poly(methyl methacrylate) (PMMA) is one of the most widely explored biomedical materials because of its biocompatibility, and recent publications have shown an increasing interest in its applications as a drug carrier. PMMA-based particulate carriers (PMMAP) can be prepared either by polymerization...

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Bibliographic Details
Published in:Journal of microencapsulation 2012-06, Vol.29 (4), p.353-367
Main Authors: Bettencourt, Ana, Almeida, António J.
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemistry
Biological and medical sciences
Drug Carriers - chemistry
Drug Carriers - toxicity
Drug Compounding - methods
drug delivery
Drug Delivery Systems
drug release kinetics
Emulsions
General pharmacology
Hydrophobic and Hydrophilic Interactions
Materials Testing
Medical sciences
Microscopy, Electron, Scanning
nano/microparticulate carriers
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
poly(methyl methacrylate) (PMMA)
Polymethyl Methacrylate - toxicity
preparation methods
toxicity
vaccine
Vaccines - administration & dosage
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Summary:Poly(methyl methacrylate) (PMMA) is one of the most widely explored biomedical materials because of its biocompatibility, and recent publications have shown an increasing interest in its applications as a drug carrier. PMMA-based particulate carriers (PMMAP) can be prepared either by polymerization methods or from pre-formed polymer-based techniques. Potential biomedical application of these particles includes their use as adjuvant for vaccines and carrier of many drugs as antibiotics and antioxidants via different routes of administration. Release of drugs from PMMAP occurs typically in a biphasic way with an incomplete drug release. To improve release profiles, recent strategies are focusing on increasing polymer hydrophilicity by synthesizing functionalized PMMA microspheres or by formulating PMMA composites with hydrophilic polymers. This review examines the current status of preparation techniques, drug release kinetics, biomedical applications and toxicity of these nano/micro PMMA-based particulate carriers.
ISSN:0265-2048
1464-5246
DOI:10.3109/02652048.2011.651500