Corpus Callosum Tissue Loss and Development of Motor and Global Cognitive Impairment: The LADIS Study

Objective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging...

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Published in:Dementia and geriatric cognitive disorders 2011-01, Vol.32 (4), p.279-286
Main Authors: Frederiksen, Kristian S., Garde, Ellen, Skimminge, Arnold, Barkhof, Frederik, Scheltens, Philip, van Straaten, Elisabeth C.W., Fazekas, Franz, Baezner, Hansjörg, Verdelho, Ana, Ferro, José M., Erkinjuntti, Timo, Jokinen, Hanna, Wahlund, Lars-Olof, O’Brien, John T., Basile, Anna M., Pantoni, Leonardo, Inzitari, Domenico, Waldemar, Gunhild
Format: Article
Language:English
Subjects:
Aged
Atrophy
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Cognition Disorders - pathology
Corpus Callosum - pathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia - pathology
Dementia - psychology
Disability Evaluation
Disease Progression
Female
Follow-Up Studies
Humans
Leukoaraiosis - pathology
Longitudinal Studies
Magnetic Resonance Imaging
Male
Medical sciences
Medicin och hälsovetenskap
Movement Disorders - pathology
Neurology
Neuropsychological Tests
Original Research Article
Pharmacology. Drug treatments
Regression Analysis
Temporal Lobe - pathology
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Summary:Objective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. Results: 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to nonconverters (p < 0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p < 0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p < 0.01). Conclusion: The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment.
ISSN:1420-8008
1421-9824
1421-9824
DOI:10.1159/000334949