The FCGR2B rs10917661 polymorphism may confer susceptibility to ankylosing spondylitis in Han Chinese: a case-control study

• Published in: Scandinavian journal of rheumatology 2012-05, Vol.41 (3), p.219-222
• Main Authors: Duan, Z-H, Pan, F-M, Zeng, Z, Zhang, T-C, Wang, S, Li, G-X, Mei, Y, Gao, J, Ge, R, Ye, D-Q, Zou, Y-F, Xu, S-Q, Xu, J-H, Zhang, L
• Format: Article
• Language: English
• Subjects: Adult; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Case-Control Studies; China - ethnology; Diseases of the osteoarticular system; Diseases of the spine; Female; Gene Frequency; Genetic Predisposition to Disease - genetics; Haplotypes - genetics; Humans; Inflammatory joint diseases; Male; Medical sciences; Polymorphism, Single Nucleotide - genetics; Receptors, IgG - genetics; Spondylitis, Ankylosing - ethnology; Spondylitis, Ankylosing - genetics; Young Adult
• ISSN: 0300-9742; 1502-7732
• DOI: 10.3109/03009742.2011.625972

Objective: Single-nucleotide polymorphisms (SNPs) in the Fc gamma receptor IIB (FCGR2B) gene have recently been found to be associated with several human autoimmune diseases. We undertook the current study to investigate the influence of these polymorphisms on the risk of ankylosing spondylitis (AS). Method: A total of 306 patients with AS from Anhui, China, fulfilling the modified New York Criteria, and 300 matched healthy controls were analysed. All subjects were genotyped for two SNPs (rs1050501, rs10917661) in the FCGR2B gene, and the SNaPshot Assay was used for genotyping. Results: SNP rs10917661 was significantly associated with AS [C vs. T: odds ratio (OR) 1.723, 95% confidence interval (CI) 1.086-2.733, p = 0.020; genotype: p = 0.026] whereas no association was found for rs1050501. Furthermore, no haplotype was found to be associated with AS. Conclusion: These findings indicated that rs10917661 may be a novel SNP involved in AS genetic predisposition in the Han Chinese population.