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The FCGR2B rs10917661 polymorphism may confer susceptibility to ankylosing spondylitis in Han Chinese: a case-control study
Objective: Single-nucleotide polymorphisms (SNPs) in the Fc gamma receptor IIB (FCGR2B) gene have recently been found to be associated with several human autoimmune diseases. We undertook the current study to investigate the influence of these polymorphisms on the risk of ankylosing spondylitis (AS)...
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Published in: | Scandinavian journal of rheumatology 2012-05, Vol.41 (3), p.219-222 |
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container_title | Scandinavian journal of rheumatology |
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creator | Duan, Z-H Pan, F-M Zeng, Z Zhang, T-C Wang, S Li, G-X Mei, Y Gao, J Ge, R Ye, D-Q Zou, Y-F Xu, S-Q Xu, J-H Zhang, L |
description | Objective: Single-nucleotide polymorphisms (SNPs) in the Fc gamma receptor IIB (FCGR2B) gene have recently been found to be associated with several human autoimmune diseases. We undertook the current study to investigate the influence of these polymorphisms on the risk of ankylosing spondylitis (AS).
Method: A total of 306 patients with AS from Anhui, China, fulfilling the modified New York Criteria, and 300 matched healthy controls were analysed. All subjects were genotyped for two SNPs (rs1050501, rs10917661) in the FCGR2B gene, and the SNaPshot Assay was used for genotyping.
Results: SNP rs10917661 was significantly associated with AS [C vs. T: odds ratio (OR) 1.723, 95% confidence interval (CI) 1.086-2.733, p = 0.020; genotype: p = 0.026] whereas no association was found for rs1050501. Furthermore, no haplotype was found to be associated with AS.
Conclusion: These findings indicated that rs10917661 may be a novel SNP involved in AS genetic predisposition in the Han Chinese population. |
doi_str_mv | 10.3109/03009742.2011.625972 |
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Method: A total of 306 patients with AS from Anhui, China, fulfilling the modified New York Criteria, and 300 matched healthy controls were analysed. All subjects were genotyped for two SNPs (rs1050501, rs10917661) in the FCGR2B gene, and the SNaPshot Assay was used for genotyping.
Results: SNP rs10917661 was significantly associated with AS [C vs. T: odds ratio (OR) 1.723, 95% confidence interval (CI) 1.086-2.733, p = 0.020; genotype: p = 0.026] whereas no association was found for rs1050501. Furthermore, no haplotype was found to be associated with AS.
Conclusion: These findings indicated that rs10917661 may be a novel SNP involved in AS genetic predisposition in the Han Chinese population.</description><identifier>ISSN: 0300-9742</identifier><identifier>EISSN: 1502-7732</identifier><identifier>DOI: 10.3109/03009742.2011.625972</identifier><identifier>PMID: 22416796</identifier><identifier>CODEN: SJRHAT</identifier><language>eng</language><publisher>Colchester: Informa Healthcare</publisher><subject>Adult ; Asian Continental Ancestry Group - genetics ; Biological and medical sciences ; Case-Control Studies ; China - ethnology ; Diseases of the osteoarticular system ; Diseases of the spine ; Female ; Gene Frequency ; Genetic Predisposition to Disease - genetics ; Haplotypes - genetics ; Humans ; Inflammatory joint diseases ; Male ; Medical sciences ; Polymorphism, Single Nucleotide - genetics ; Receptors, IgG - genetics ; Spondylitis, Ankylosing - ethnology ; Spondylitis, Ankylosing - genetics ; Young Adult</subject><ispartof>Scandinavian journal of rheumatology, 2012-05, Vol.41 (3), p.219-222</ispartof><rights>2012 Taylor & Francis on license from Scandinavian Rheumatology Research Foundation 2012</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-1921b28cd5657d2b10d0c85213227c314ac8e95661735f92a7c5f46a1df316423</citedby><cites>FETCH-LOGICAL-c378t-1921b28cd5657d2b10d0c85213227c314ac8e95661735f92a7c5f46a1df316423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25867946$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22416796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duan, Z-H</creatorcontrib><creatorcontrib>Pan, F-M</creatorcontrib><creatorcontrib>Zeng, Z</creatorcontrib><creatorcontrib>Zhang, T-C</creatorcontrib><creatorcontrib>Wang, S</creatorcontrib><creatorcontrib>Li, G-X</creatorcontrib><creatorcontrib>Mei, Y</creatorcontrib><creatorcontrib>Gao, J</creatorcontrib><creatorcontrib>Ge, R</creatorcontrib><creatorcontrib>Ye, D-Q</creatorcontrib><creatorcontrib>Zou, Y-F</creatorcontrib><creatorcontrib>Xu, S-Q</creatorcontrib><creatorcontrib>Xu, J-H</creatorcontrib><creatorcontrib>Zhang, L</creatorcontrib><title>The FCGR2B rs10917661 polymorphism may confer susceptibility to ankylosing spondylitis in Han Chinese: a case-control study</title><title>Scandinavian journal of rheumatology</title><addtitle>Scand J Rheumatol</addtitle><description>Objective: Single-nucleotide polymorphisms (SNPs) in the Fc gamma receptor IIB (FCGR2B) gene have recently been found to be associated with several human autoimmune diseases. We undertook the current study to investigate the influence of these polymorphisms on the risk of ankylosing spondylitis (AS).
Method: A total of 306 patients with AS from Anhui, China, fulfilling the modified New York Criteria, and 300 matched healthy controls were analysed. All subjects were genotyped for two SNPs (rs1050501, rs10917661) in the FCGR2B gene, and the SNaPshot Assay was used for genotyping.
Results: SNP rs10917661 was significantly associated with AS [C vs. T: odds ratio (OR) 1.723, 95% confidence interval (CI) 1.086-2.733, p = 0.020; genotype: p = 0.026] whereas no association was found for rs1050501. Furthermore, no haplotype was found to be associated with AS.
Conclusion: These findings indicated that rs10917661 may be a novel SNP involved in AS genetic predisposition in the Han Chinese population.</description><subject>Adult</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>China - ethnology</subject><subject>Diseases of the osteoarticular system</subject><subject>Diseases of the spine</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Haplotypes - genetics</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Receptors, IgG - genetics</subject><subject>Spondylitis, Ankylosing - ethnology</subject><subject>Spondylitis, Ankylosing - genetics</subject><subject>Young Adult</subject><issn>0300-9742</issn><issn>1502-7732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqFkM1u1DAURi0EokPhDRDyBolNBv_EccyCCka0RaqEhMo68jgOcXHs4JsIRX35OpoZEBtYeXHP9_neg9BLSracEvWWcEKULNmWEUq3FRNKskdoQwVhhZScPUabFSlW5gw9A7gjhJRKqqfojLGSVlJVG3R_21t8ubv6yj7iBLmXyqqieIx-GWIaewcDHvSCTQydTRhmMHac3N55Ny14iliHH4uP4MJ3DGMM7ZIHDrAL-FoHvOtdsGDfYY2NBlvkmilFj2Ga2-U5etJpD_bF8T1H3y4_3e6ui5svV593H24Kw2U9FVQxume1aUUlZMv2lLTE1IJRzpg0nJba1FaJvLbkolNMSyO6stK07TitSsbP0ZtD75jiz9nC1Awun-G9DjbO0NAskEpBVJ3R8oCaFAGS7ZoxuUGnJUPNqr05aW9W7c1Be469Ov4w7wfb_g6dPGfg9RHQYLTvkg7GwR9O1BkrV-7iwLnQxTToXzH5tpl0VpxOIf6fVd7_1dBb7afe6GSbuzinkEX_-5YHkRqwPQ</recordid><startdate>201205</startdate><enddate>201205</enddate><creator>Duan, Z-H</creator><creator>Pan, F-M</creator><creator>Zeng, Z</creator><creator>Zhang, T-C</creator><creator>Wang, S</creator><creator>Li, G-X</creator><creator>Mei, Y</creator><creator>Gao, J</creator><creator>Ge, R</creator><creator>Ye, D-Q</creator><creator>Zou, Y-F</creator><creator>Xu, S-Q</creator><creator>Xu, J-H</creator><creator>Zhang, L</creator><general>Informa Healthcare</general><general>Taylor & Francis</general><general>Informa</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201205</creationdate><title>The FCGR2B rs10917661 polymorphism may confer susceptibility to ankylosing spondylitis in Han Chinese: a case-control study</title><author>Duan, Z-H ; Pan, F-M ; Zeng, Z ; Zhang, T-C ; Wang, S ; Li, G-X ; Mei, Y ; Gao, J ; Ge, R ; Ye, D-Q ; Zou, Y-F ; Xu, S-Q ; Xu, J-H ; Zhang, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-1921b28cd5657d2b10d0c85213227c314ac8e95661735f92a7c5f46a1df316423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>China - ethnology</topic><topic>Diseases of the osteoarticular system</topic><topic>Diseases of the spine</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Haplotypes - genetics</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Receptors, IgG - genetics</topic><topic>Spondylitis, Ankylosing - ethnology</topic><topic>Spondylitis, Ankylosing - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duan, Z-H</creatorcontrib><creatorcontrib>Pan, F-M</creatorcontrib><creatorcontrib>Zeng, Z</creatorcontrib><creatorcontrib>Zhang, T-C</creatorcontrib><creatorcontrib>Wang, S</creatorcontrib><creatorcontrib>Li, G-X</creatorcontrib><creatorcontrib>Mei, Y</creatorcontrib><creatorcontrib>Gao, J</creatorcontrib><creatorcontrib>Ge, R</creatorcontrib><creatorcontrib>Ye, D-Q</creatorcontrib><creatorcontrib>Zou, Y-F</creatorcontrib><creatorcontrib>Xu, S-Q</creatorcontrib><creatorcontrib>Xu, J-H</creatorcontrib><creatorcontrib>Zhang, L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duan, Z-H</au><au>Pan, F-M</au><au>Zeng, Z</au><au>Zhang, T-C</au><au>Wang, S</au><au>Li, G-X</au><au>Mei, Y</au><au>Gao, J</au><au>Ge, R</au><au>Ye, D-Q</au><au>Zou, Y-F</au><au>Xu, S-Q</au><au>Xu, J-H</au><au>Zhang, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The FCGR2B rs10917661 polymorphism may confer susceptibility to ankylosing spondylitis in Han Chinese: a case-control study</atitle><jtitle>Scandinavian journal of rheumatology</jtitle><addtitle>Scand J Rheumatol</addtitle><date>2012-05</date><risdate>2012</risdate><volume>41</volume><issue>3</issue><spage>219</spage><epage>222</epage><pages>219-222</pages><issn>0300-9742</issn><eissn>1502-7732</eissn><coden>SJRHAT</coden><abstract>Objective: Single-nucleotide polymorphisms (SNPs) in the Fc gamma receptor IIB (FCGR2B) gene have recently been found to be associated with several human autoimmune diseases. We undertook the current study to investigate the influence of these polymorphisms on the risk of ankylosing spondylitis (AS).
Method: A total of 306 patients with AS from Anhui, China, fulfilling the modified New York Criteria, and 300 matched healthy controls were analysed. All subjects were genotyped for two SNPs (rs1050501, rs10917661) in the FCGR2B gene, and the SNaPshot Assay was used for genotyping.
Results: SNP rs10917661 was significantly associated with AS [C vs. T: odds ratio (OR) 1.723, 95% confidence interval (CI) 1.086-2.733, p = 0.020; genotype: p = 0.026] whereas no association was found for rs1050501. Furthermore, no haplotype was found to be associated with AS.
Conclusion: These findings indicated that rs10917661 may be a novel SNP involved in AS genetic predisposition in the Han Chinese population.</abstract><cop>Colchester</cop><pub>Informa Healthcare</pub><pmid>22416796</pmid><doi>10.3109/03009742.2011.625972</doi><tpages>4</tpages></addata></record> |
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subjects | Adult Asian Continental Ancestry Group - genetics Biological and medical sciences Case-Control Studies China - ethnology Diseases of the osteoarticular system Diseases of the spine Female Gene Frequency Genetic Predisposition to Disease - genetics Haplotypes - genetics Humans Inflammatory joint diseases Male Medical sciences Polymorphism, Single Nucleotide - genetics Receptors, IgG - genetics Spondylitis, Ankylosing - ethnology Spondylitis, Ankylosing - genetics Young Adult |
title | The FCGR2B rs10917661 polymorphism may confer susceptibility to ankylosing spondylitis in Han Chinese: a case-control study |
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