Manzamines: A potential for novel cures

Manzamines are a unique class of β-carboline marine alkaloids with an unusual tetra- or pentacyclic system. These alkaloids have shown a variety of bioactivities against infectious diseases, cancer and inflammatory diseases. The greatest potential for the manzamine alkaloids appears to be against ma...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2012-05, Vol.11 (9), p.1765-1772
Main Authors: Radwan, Mona, Hanora, Amro, Khalifa, Sherief, Abou-El-Ela, Soad H.
Format: Article
Language:English
Subjects:
Actinobacteria - chemistry
Actinobacteria - isolation & purification
alkaloids
Animals
Anti-Infective Agents - chemistry
Anti-Infective Agents - isolation & purification
Anti-Infective Agents - pharmacology
antimalarial
Antimalarials - chemistry
Antimalarials - isolation & purification
Antimalarials - pharmacology
Binding
Biological Products - chemistry
Biological Products - isolation & purification
Biological Products - pharmacology
Biology
Bioscience
biosynthetic gene clusters
Biota
Calcium
Cancer
Carbazoles - chemistry
Carbazoles - isolation & purification
Carbazoles - pharmacology
Carbolines - chemistry
Cell
Cycle
Indian Ocean
Indole Alkaloids - chemistry
Indole Alkaloids - isolation & purification
Indole Alkaloids - pharmacology
Landes
Malaria - drug therapy
manzamines
Marine Biology
marine sponges
microbial origin
Organogenesis
Porifera - chemistry
Porifera - microbiology
Proteins
Red Sea biota
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Description
Summary:Manzamines are a unique class of β-carboline marine alkaloids with an unusual tetra- or pentacyclic system. These alkaloids have shown a variety of bioactivities against infectious diseases, cancer and inflammatory diseases. The greatest potential for the manzamine alkaloids appears to be against malaria, with improved potency relative to chloroquine and artemisinin. Over 80 manzamine-related alkaloids have been isolated from more than 16 species of marine sponges belonging to five families distributed from the Red Sea to Indonesia, which suggests a possible microbial origin for manzamine alkaloids. The current review summarizes marine literature, focusing on the biological activities of manzamines, the possible microbial origin of this class of compounds and the Red Sea as a possible source of manzamines from biosynthetic gene clusters of Red Sea microbes.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.20135