Association Between the Markers of FIRS and the Morphologic Alterations in the Liver of Neonates Autopsied in the Perinatal Period

• Published in: Fetal and pediatric pathology 2013-02, Vol.32 (1), p.48-54
• Main Authors: Morais Pereira, Lívia Helena de, Pacheco Olegário, Janaínna Grazielle, Rocha, Laura Penna, de Oliveira Guimarães, Camila Souza, Ramalho, Fernando Silva, dos Reis, Marlene Antônia, Miranda Corrêa, Rosana Rosa
• Format: Article
• Language: English
• Subjects: Autopsy; Biomarkers - analysis; C-Reactive Protein - analysis; C-Reactive Protein - biosynthesis; collagen; extramedullary erythropoiesis; Female; fetal inflammatory response syndrome (FIRS); Humans; Infant, Newborn; Infant, Newborn, Diseases - metabolism; Infant, Newborn, Diseases - pathology; Interleukin-6 - analysis; Interleukin-6 - biosynthesis; Liver - metabolism; Liver - pathology; Male; Pregnancy; Pregnancy Complications - metabolism; Pregnancy Complications - pathology; steatosis; Syndrome; Tumor Necrosis Factor-alpha - analysis; Tumor Necrosis Factor-alpha - biosynthesis
• ISSN: 1551-3815; 1551-3823
• DOI: 10.3109/15513815.2012.659536

Markers of fetal inflammatory response syndrome (FIRS) can influence the morphologic alterations in liver of autopsied neonates. The IL-6, TNF-α, and C-reactive protein (CRP) expression in liver fragments were marked by immunohistochemistry and the intensity of steatosis, percentage of fibrosis, and the number of foci of extramedullary erythropoiesis were evaluated. The degree of steatosis correlated positively with IL-6 (p = 0.06), positively with CRP (p ≤ 0.001), and negatively with TNF-α (p = 0.06). The collagen percentage correlated positively with IL-6 (p = 0.055) and positively with TNF-α (p ≤ 0.001). Erythropoiesis correlated positively with IL-6 (p ≤ 0.001) and negatively with CRP (p = 0.00754). The analyzed markers of FIRS have an important role in triggering hepatic morphologic alterations.