Mucosal Vaccine Design and Delivery

Mucosal surfaces are a major portal of entry for many human pathogens that are the cause of infectious diseases worldwide. Vaccines capable of eliciting mucosal immune responses can fortify defenses at mucosal front lines and protect against infection. However, most licensed vaccines are administere...

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Bibliographic Details
Published in:Annual review of biomedical engineering 2012-08, Vol.14 (1), p.17-46
Main Authors: Woodrow, Kim A, Bennett, Kaila M, Lo, David D
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Animals
Antigen-Presenting Cells - immunology
biomaterial vaccine vectors
Dendritic Cells - cytology
Epithelium - immunology
Humans
Immunity - immunology
Immunity, Mucosal - immunology
Immunization
Kinetics
Models, Biological
mucosal adjuvant
mucosal immunity
Mucous Membrane - immunology
Mucous Membrane - pathology
Nanocapsules - chemistry
particulate delivery
Polymers - chemistry
Vaccination
Vaccines - administration & dosage
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Summary:Mucosal surfaces are a major portal of entry for many human pathogens that are the cause of infectious diseases worldwide. Vaccines capable of eliciting mucosal immune responses can fortify defenses at mucosal front lines and protect against infection. However, most licensed vaccines are administered parenterally and fail to elicit protective mucosal immunity. Immunization by mucosal routes may be more effective at inducing protective immunity against mucosal pathogens at their sites of entry. Recent advances in our understanding of mucosal immunity and identification of correlates of protective immunity against specific mucosal pathogens have renewed interest in the development of mucosal vaccines. Efforts have focused on efficient delivery of vaccine antigens to mucosal sites that facilitate uptake by local antigen-presenting cells to generate protective mucosal immune responses. Discovery of safe and effective mucosal adjuvants are also being sought to enhance the magnitude and quality of the protective immune response.
ISSN:1523-9829
1545-4274
DOI:10.1146/annurev-bioeng-071811-150054