Predictors of the Short-Term Effect of Isoleucine-Proline-Proline/Valine-Proline-Proline Lactotripeptides from Casein on Office and Ambulatory Blood Pressure in Subjects with Pharmacologically Untreated High-Normal Blood Pressure or First-Degree Hypertension

Our aim was to evaluate the predictors of Isoleucine-Proline-Proline/Valine-Proline-Proline (IPP-VPP) lactotripeptides (LTPs) antihypertensive effect in the context of a short-term large double-blind randomized clinical trial involving 164 pharmacologically untreated subjects in primary prevention f...

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Bibliographic Details
Published in:Clinical and experimental hypertension (1993) 2012-01, Vol.34 (8), p.601-605
Main Authors: Cicero, A. F. G., Rosticci, M., Ferroni, A., Bacchelli, S., Veronesi, M., Strocchi, E., Borghi, C.
Format: Article
Language:English
Subjects:
ABPM
Adult
Aged
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
blood pressure
Blood Pressure - drug effects
Blood Pressure Monitoring, Ambulatory
Cardiovascular Diseases - prevention & control
Caseins - chemistry
Double-Blind Method
Female
Humans
Hypertension - classification
Hypertension - diagnosis
Hypertension - drug therapy
lactotripeptides
Male
Middle Aged
Office Visits
Oligopeptides - therapeutic use
Predictive Value of Tests
predictors
Time Factors
Treatment Outcome
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Summary:Our aim was to evaluate the predictors of Isoleucine-Proline-Proline/Valine-Proline-Proline (IPP-VPP) lactotripeptides (LTPs) antihypertensive effect in the context of a short-term large double-blind randomized clinical trial involving 164 pharmacologically untreated subjects in primary prevention for cardiovascular disease. When compared with the baseline, office systolic blood pressure (SBP) (−3.42 mm Hg, P < .001) and diastolic blood pressure (DBP) (−2.35 mm Hg, P < .001) significantly decreased, in the LTP-treated patients only. No significant change in predictors during the study of ambulatory blood pressure measurement (ABPM) parameters was observed. A short-term supplementation with LTPs significantly improves the office SBP and DBP, especially in male subjects. The main predictor of LTP antihypertensive effect was the baseline BP.
ISSN:1064-1963
1525-6006
DOI:10.3109/10641963.2012.681731