Spectrum of Autoantibodies in Tunisian Psychiatric Inpatients

One hundred and three psychiatric inpatients (74 men) were assessed for a wide spectrum of autoantibodies including antinuclear, antismooth muscle, antimitochondrial, antiDNA, anti-phospholipid, anti-cardiolipin IgG and IgM, antikeratin, rheumatoid factor, antithyroperoxydase, antigliadin IgA and Ig...

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Bibliographic Details
Published in:Immunological investigations 2012-07, Vol.41 (5), p.538-549
Main Authors: Sidhom, Oussama, Laadhar, Lilia, Zitouni, Mondher, Ben Alaya, Nissaf, Rafrafi, Rym, Kallel-Sellami, Marayam, Lahmar, Houria, El Hechmi, Zouhair, Makni, Sondes
Format: Article
Language:English
Subjects:
Adult
Autoantibodies - blood
Autoimmunity
Bipolar disorder
Female
Humans
Immunoglobulins - blood
Immunology
Life Sciences
Male
Mental Disorders - blood
Mental Disorders - immunology
Middle Aged
Schizophrenia
Tunisia - epidemiology
Young Adult
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Summary:One hundred and three psychiatric inpatients (74 men) were assessed for a wide spectrum of autoantibodies including antinuclear, antismooth muscle, antimitochondrial, antiDNA, anti-phospholipid, anti-cardiolipin IgG and IgM, antikeratin, rheumatoid factor, antithyroperoxydase, antigliadin IgA and IgG, antitransgutaminase, and antiendomysium antibodies. Four groups of patients were considered separately, including 47 with schizophrenia, 23 with schizoaffective disorder, 16 with bipolar disorder and 17 patients with other different psychiatric diagnosis. Forty one healthy, age- and sex-matched blood donors were used as a control group. There were no significant difference in the prevalence of the different autoantibodies between patients (N = 103) and controls except for antigliadin IgG (30.1 vs 9.8 respectively, p = 0.01). Presence of autoantibodies was influenced by age but not by sex or treatment. As for diagnosis categories, patients with bipolar disorder presented significantly more autoantibodies than the three other categories and controls. These results point out a possible autoimmune activation in at least a subgroup of psychiatric patients especially amongst those suffering from bipolar disorder.
ISSN:0882-0139
1532-4311
DOI:10.3109/08820139.2012.685537