Diversin, from Ferula diversivittata protects human lymphocytes against oxidative stress induced by H₂O

In this study, the antigenotoxic effects of diversin, a prenylated coumarin obtained from Ferula diversivittata roots were evaluated using comet assay. Isolated lymphocytes from healthy volunteers' blood samples were incubated with diversin (10, 25, 50, 100, 200 and 400 µM) alone, or in the pre...

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Bibliographic Details
Published in:Natural product research 2013, Vol.27 (11), p.1016
Main Authors: Zarei, Hassan, Rezaee, Ramin, Behravan, Effat, Soltani, Fatemeh, Mosaffa, Fatemeh, Iranshahi, Mehrdad, Behravan, Javad
Format: Article
Language:English
Subjects:
Coumarins - metabolism
Humans
Hydrogen Peroxide - pharmacology
Lymphocytes - physiology
Monoterpenes - metabolism
Oxidative Stress
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Summary:In this study, the antigenotoxic effects of diversin, a prenylated coumarin obtained from Ferula diversivittata roots were evaluated using comet assay. Isolated lymphocytes from healthy volunteers' blood samples were incubated with diversin (10, 25, 50, 100, 200 and 400 µM) alone, or in the presence of H2O2 (25 µM). DNA break was measured based on the %tail DNA and compared with different concentrations of curcumin (10, 25 and 50 µM) as the positive control. It was shown that all concentrations of diversin significantly reduce DNA damage caused by H2O2.
ISSN:1478-6427
DOI:10.1080/14786419.2012.688053