Randomized Double-Blind Clinical Trial of Autologous Serum Versus Artificial Tears in Dry Eye Syndrome

Purpose: To determine symptoms improvement in dry eye patients with short-term autologous serum (AS) eyedrops treatment using the standardized Ocular Surface Disease Index (OSDI) survey. Materials and methods: A double-blind randomized crossover clinical trial was conducted, comparing short-term (2...

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Bibliographic Details
Published in:Current eye research 2012-08, Vol.37 (8), p.684-688
Main Authors: Urzua, Cristhian A., Vasquez, Dario H., Huidobro, Andres, Hernandez, Helio, Alfaro, Jorge
Format: Article
Language:English
Subjects:
Artificial tears
Autologous serum
Conjunctiva - metabolism
Cornea - metabolism
Cross-Over Studies
Double-Blind Method
Dry eye syndrome
Dry Eye Syndromes - physiopathology
Dry Eye Syndromes - therapy
Female
Fluorescein - metabolism
Fluorophotometry
Humans
Male
Middle Aged
Ocular surface
Ophthalmic Solutions - administration & dosage
OSDI
Serum
Treatment Outcome
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Summary:Purpose: To determine symptoms improvement in dry eye patients with short-term autologous serum (AS) eyedrops treatment using the standardized Ocular Surface Disease Index (OSDI) survey. Materials and methods: A double-blind randomized crossover clinical trial was conducted, comparing short-term (2 weeks) topical treatment with AS eyedrops diluted at 20% versus conventional artificial tears treatment in adult severe dry eye syndrome (DES) patients. The main outcome measure was assessment of symptoms with OSDI survey. Secondary outcomes were corneal and conjunctival fluorescein staining score of OXFORD and tear break up time (TBUT). The protocol was registered in www.clinicaltrials.gov, ID number: NCT00779987. Results: Twelve severe DES patients were included. Autologous serum treatment showed a statistically significant (p = 0.002) higher OSDI decrease (50%) versus conventional treatment (22%). There were no significant changes in objectives parameters (OXFORD and TBUT). Conclusions: Severe DES patients treated with AS achieve better symptoms improvement compared to artificial tears in a short-term treatment.
ISSN:0271-3683
1460-2202
DOI:10.3109/02713683.2012.674609