IL-33/ST2 axis in innate and acquired immunity to tumors

Interleukin-33, a ligand for ST2/T1, has an important role in allergy, autoimmunity and inflammation. The role of IL-33/ST2 axis in cancer is not elucidated. Using metastatic breast cancer model we provide evidence that lack of ST2 signaling led to reduced tumor growth and metastasis and enhanced an...

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Bibliographic Details
Published in:Oncoimmunology 2012-03, Vol.1 (2), p.229-231
Main Authors: Jovanovic, Ivan P., Pejnovic, Nada N., Radosavljevic, Gordana D., Arsenijevic, Nebojsa N., Lukic, Miodrag L.
Format: Article
Language:English
Subjects:
4T1 mouse breast cancer
Author's View
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
cytotoxic response
IL-33
Landes
NK cells
Organogenesis
Proteins
ST2L
Th1/Th2 cells
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Summary:Interleukin-33, a ligand for ST2/T1, has an important role in allergy, autoimmunity and inflammation. The role of IL-33/ST2 axis in cancer is not elucidated. Using metastatic breast cancer model we provide evidence that lack of ST2 signaling led to reduced tumor growth and metastasis and enhanced anti-tumor immunity.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/onci.1.2.18131