Alpha-dephenzine concentration in peripheral blood of patients diagnosed with schizophrenia

Over the past few decades the search for predisposed biological markers has become the course of most priority in scientific psychiatry. Research goal was to reveal the association of alpha-dephenzine concentration in peripheral blood with the disease existence and its progressing (acute and chronic...

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Bibliographic Details
Published in:Georgian medical news 2012-06 (207), p.22
Main Authors: Bzhalava, B L, Petriashvili, Sh G, Gurtskaia, Z T, Zurabashvili, D Z, Chikadze, N R
Format: Article
Language:Russian
Subjects:
Adult
alpha-Defensins - blood
Biomarkers - blood
Female
Humans
Male
Middle Aged
Schizophrenia - blood
Schizophrenia - physiopathology
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Summary:Over the past few decades the search for predisposed biological markers has become the course of most priority in scientific psychiatry. Research goal was to reveal the association of alpha-dephenzine concentration in peripheral blood with the disease existence and its progressing (acute and chronic forms) in patients with schizophrenia. In-patients diagnosed with schizophrenia have been investigated (av. age - 45.33±1.86), among them 26 males (av. age - 39.41±1.86) and 13 females (av. age - 45.04±2.44). 27 patients with acute form of schizophrenia (av.age - 44.88±2.42), 12 patients with a chronic form (av. age - 46.33±2.75). 15 healthy volunteers have been investigated as well (av.age - 40.03±2.94), 5 males and 10 females among them. The study of alpha-dephenzine concentration by the immunoenzyme method has been implied in the investigation. Research studies revealed statistically valid increased concentration of alpha-dephenzine in patients diagnosed with schizophrenia comparing with healthy volunteers. The difference was so evident that qualitative difference (marker existence-nonexistence) would rather be considered than quantitative one. Relying on the results of studies we can estimate alpha-dephenzines as possible biomarkers of schizophrenia.
ISSN:1512-0112