In Vivo Fluorescence Imaging with Ag2S Quantum Dots in the Second Near-Infrared Region

Hits the dot: Ag2S quantum dots (QDs) with bright near‐infrared‐II fluorescence emission (around 1200 nm) and six‐arm branched PEG surface coating (see scheme) were synthesized for in vivo small‐animal imaging. The 6PEG‐Ag2S QDs afforded a tumor uptake of approximately 10 % injected dose/gram, owing...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-09, Vol.51 (39), p.9818-9821
Main Authors: Hong, Guosong, Robinson, Joshua T., Zhang, Yejun, Diao, Shuo, Antaris, Alexander L., Wang, Qiangbin, Dai, Hongjie
Format: Article
Language:English
Subjects:
Animals
Female
fluorescence
Fluorescent Dyes - chemistry
in vivo imaging
Mice
Mice, Inbred BALB C
Neoplasms - diagnosis
Optical Imaging - methods
Quantum Dots
second near-infrared window
Silver Compounds - chemistry
Spectroscopy, Near-Infrared - methods
tumor imaging
Online Access:Get full text
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Summary:Hits the dot: Ag2S quantum dots (QDs) with bright near‐infrared‐II fluorescence emission (around 1200 nm) and six‐arm branched PEG surface coating (see scheme) were synthesized for in vivo small‐animal imaging. The 6PEG‐Ag2S QDs afforded a tumor uptake of approximately 10 % injected dose/gram, owing to a long circulation half‐life of approximately 4 h. Clearance of the injected 6PEG‐Ag2S QDs occurs mainly through the biliary pathway in mice.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201206059