Functional significance of periostin in excisional skin repair: Is the devil in the detail?

In the past year, three papers have been published exploring the role of the matricellular protein periostin in excisional skin repair. These papers all show a delay in wound closure and the kinetics of this delay are strikingly similar across the three reports. The similarities between these papers...

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Bibliographic Details
Published in:Cell adhesion & migration 2012-07, Vol.6 (4), p.319-326
Main Authors: Elliott, Christopher G., Kim, Shawna S., Hamilton, Douglas W.
Format: Article
Language:English
Subjects:
Animals
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cell Adhesion Molecules - genetics
Cell Adhesion Molecules - metabolism
Cell Adhesion Molecules - physiology
Cell Differentiation
Cell Movement
Cell Proliferation
Cells, Cultured
Cycle
Fibroblasts - metabolism
Fibroblasts - physiology
Gene Expression
Humans
Keratinocytes - metabolism
Keratinocytes - physiology
Landes
migration
Models, Biological
myofibroblast
Myofibroblasts - metabolism
Myofibroblasts - physiology
Organogenesis
periostin
proliferation
Proteins
Skin - pathology
Skin - physiopathology
skin repair
Up-Regulation
Wound Healing
Citations: Items that this one cites
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Summary:In the past year, three papers have been published exploring the role of the matricellular protein periostin in excisional skin repair. These papers all show a delay in wound closure and the kinetics of this delay are strikingly similar across the three reports. The similarities between these papers end, however, when each investigates the mechanism through which periostin influences skin repair. Three proposed mechanisms have been identified: (1) myofibroblast differentiation, (2) keratinocyte proliferation and (3) fibroblast proliferation and migration. The aim of this commentary is to compare and contrast the three studies performed to date in an attempt to decipher the role of periostin in the repair of full-thickness skin wounds.
ISSN:1933-6918
1933-6926
DOI:10.4161/cam.20879