PRDM9 gene polymorphism may not be associated with defective spermatogenesis in the Chinese Han population

PRDM9 is essential for the progression through early meiotic prophase, including double strand break repair, homologous chromosome pairing, and sex body formation during spermatogenesis. In order to evaluate the association of the PRDM9 gene variants with defective spermatogenesis in the Chinese Han...

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Bibliographic Details
Published in:Systems biology in reproductive medicine 2013-02, Vol.59 (1), p.38-41
Main Authors: He, Xiao-Jin, Ruan, Jian, Du, Wei-Dong, Cao, Yun-Xia, Chen, Gang, Zuo, Xian-Bo, Peng, Yu-Wan, Wu, Huan, Song, Bing, Zhang, Xue-Jun
Format: Article
Language:English
Subjects:
Adult
Asian Continental Ancestry Group - genetics
Azoospermia - genetics
Female
Gene Frequency
Genetic Predisposition to Disease
Histone-Lysine N-Methyltransferase - genetics
Humans
Male
Oligospermia - genetics
Polymorphism, Single Nucleotide
Spermatogenesis - genetics
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Summary:PRDM9 is essential for the progression through early meiotic prophase, including double strand break repair, homologous chromosome pairing, and sex body formation during spermatogenesis. In order to evaluate the association of the PRDM9 gene variants with defective spermatogenesis in the Chinese Han population, we assessed two single nucleotide polymorphisms (SNPs) in the PRDM9 gene (rs1874165 and rs2973631) using Sequenom iplex technology in 309 cases of severely defective spermatogenesis (199 cases with non-obstructive azoospermia and 110 cases with severe oligozoospermia) and 377 controls. The allele frequencies of the SNPs were not statistically different between the study groups and the controls (P = 0.95 in rs1874165 and P = 0.80 in rs2973631, respectively). The genetic model analysis of the two SNPs indicated that these SNPs variants may not be associated with defective spermatogenesis in the Chinese Han population.
ISSN:1939-6368
1939-6376
DOI:10.3109/19396368.2012.723793