Occurrence and distribution of pilomyxoid astrocytoma

Abstract Purpose. To know the occurrence and distribution of Pilomyxoid Astrocytomas amongst tumours previously diagnosed histologically as Pilocytic Astrocytoma and to assess the clinical impact of this new entity. Methods. Retrospective Diagnostic review of all cases histologically diagnosed as WH...

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Bibliographic Details
Published in:British journal of neurosurgery 2013-08, Vol.27 (4), p.413-418
Main Authors: Bhargava, D., Sinha, P., Chumas, P., Al-Tamimi, Y., Shivane, A., Chakrabarty, A., Surash, S., Novegno, F., Crimmins, D., Tyagi, A. K.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
astrocytoma
Astrocytoma - classification
Astrocytoma - epidemiology
Astrocytoma - mortality
Astrocytoma - pathology
Brain
Child
Child, Preschool
Female
Humans
Hypothalamic Neoplasms - epidemiology
Hypothalamic Neoplasms - mortality
Hypothalamic Neoplasms - pathology
Incidence
Infant
Magnetic Resonance Imaging
Male
Medical diagnosis
Middle Aged
Mucus
Neoplasm Grading
Neoplasm Recurrence, Local
Neoplasm Staging
Neurosurgery
Optic Nerve Neoplasms - epidemiology
Optic Nerve Neoplasms - mortality
Optic Nerve Neoplasms - pathology
pilocytic
pilomyxoid
Retrospective Studies
Tumors
Young Adult
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Summary:Abstract Purpose. To know the occurrence and distribution of Pilomyxoid Astrocytomas amongst tumours previously diagnosed histologically as Pilocytic Astrocytoma and to assess the clinical impact of this new entity. Methods. Retrospective Diagnostic review of all cases histologically diagnosed as WHO Grade I Astrocytoma at a single Neurosurgical unit between 1990 and 2003. Results. Of a total of 91 cases identified, 9 were found to have Pilomyxoid histology. Of these, 8 were children (mean age 3.33 years) and 1 adult. 6 tumours were hypothalamochiasmatic in location. The clinical course of Pilomyxoid tumours was aggressive marked by maturation, multiple recurrences and disease control was rarely achieved with single treatment modality as opposed to typical pilocytics. The overall survival of the pilomyxoid group was not statistically different from the pilocytic tumours. Conclusions. Encompassing all age-groups and locations, Pilomyxoid Astrocytomas constitute about 10% of all tumours previously diagnosed as Pilocytic Astrocytoma. Nearly two-thirds are hypothalamo-chiasmatic in location. Knowledge of this entity is essential for appropriate aggressive treatment and follow-up.
ISSN:0268-8697
1360-046X
DOI:10.3109/02688697.2012.752430