A conceptual framework for analysing and planning synthetic approaches to diverse lead-like scaffolds

Historically, chemists' exploration of chemical space has been exceptionally uneven and unsystematic. This feature article outlines a comprehensive conceptual framework that may be used to capture, analyse and plan synthetic approaches that may address this historically uneven exploration. Illu...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2013-03, Vol.49 (24), p.2383-2393
Main Authors: MacLellan, Paul, Nelson, Adam
Format: Article
Language:English
Subjects:
Amination
Boundaries
Bridged Bicyclo Compounds - chemical synthesis
Bridged Bicyclo Compounds - chemistry
Catalysis
Chemists
Combinatorial analysis
Cyclization
Cycloaddition Reaction
Exploration
Heterocyclic Compounds - chemical synthesis
Heterocyclic Compounds - chemistry
Metals - chemistry
Models, Chemical
Pyrrolidinones - chemical synthesis
Pyrrolidinones - chemistry
Scaffolds
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Summary:Historically, chemists' exploration of chemical space has been exceptionally uneven and unsystematic. This feature article outlines a comprehensive conceptual framework that may be used to capture, analyse and plan synthetic approaches that may address this historically uneven exploration. Illustrative examples of synthetic approaches that target, or have potential to target, broad tracts of lead-like chemical space are presented within the context of this conceptual framework. Particular emphasis is placed on synthetic approaches that enable the combinatorial variation of molecular scaffold, particularly within the boundaries of lead-like chemical space. Historically, chemists' exploration of chemical space has been exceptionally uneven and unsystematic.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc38184b