Correlates of 25-Hydroxyvitamin D and Breast Cancer Stage in the Women's Healthy Eating and Living Study

Inverse associations between circulating 25-hydroxyvitamin D [25(OH)D] and breast cancer stage have been reported, thus it is critical to understand the variables that contribute to 25(OH)D levels among women with breast cancer. Among 904 women in the Women's Healthy Eating and Living Study, pl...

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Bibliographic Details
Published in:Nutrition and cancer 2013, Vol.65 (2), p.188-194
Main Authors: Jacobs, Elizabeth T., Thomson, Cynthia A., Flatt, Shirley W., Newman, Vicky A., Rock, Cheryl L., Pierce, John P.
Format: Article
Language:English
Subjects:
Adult
Aged
Arizona
Body Mass Index
Breast cancer
Breast Neoplasms - blood
Breast Neoplasms - etiology
Breast Neoplasms - pathology
California
Correlation analysis
Diet
Female
Humans
Middle Aged
Neoplasm Staging
Oregon
Plasma
Regression Analysis
Texas
Tumors
Vitamin D
Vitamin D - administration & dosage
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
Women
Young Adult
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Summary:Inverse associations between circulating 25-hydroxyvitamin D [25(OH)D] and breast cancer stage have been reported, thus it is critical to understand the variables that contribute to 25(OH)D levels among women with breast cancer. Among 904 women in the Women's Healthy Eating and Living Study, plasma 25(OH)D concentrations were measured and data on demographic characteristics, diet, physical activity, and tumor characteristics were collected at study entry. Statistically significant associations with 25(OH)D concentrations were observed for body mass index (BMI), body surface area (BSA), height, smoking, total vitamin D intake, physical activity, and race or ethnicity. Of the correlates of 25(OH)D, BMI, BSA, height, physical activity, and study site were associated with stage of breast cancer; however, concentrations of 25(OH)D were not significantly related to stage. In fully adjusted logistic regression models, the ORs (95% CIs) for the association between vitamin D deficiency and Stage II and III cancers were 0.85 (0.59-1.22) and 1.23 (0.71-2.15), respectively (P trend = 0.59), compared to Stage I. This study confirms previous work regarding the correlates of 25(OH)D concentrations but does not provide support for an association between vitamin D status and breast cancer stage.
ISSN:0163-5581
1532-7914
DOI:10.1080/01635581.2013.756531