Immunological Studies of Reactive Oxygen Species Damaged Catalase in Patients with Systemic Lupus Erythematosus: Correlation with Disease Activity Index

Objectives: This study was undertaken to investigate the status and contribution of oxidized catalase in systemic lupus erythematosus (SLE) and to explore whether oxidized catalase has a role in disease progression. Methods: Catalase (CAT) was modified by reactive oxygen species (ROS). Sera from 50...

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Published in:Immunological investigations 2013-01, Vol.42 (3), p.191-203
Main Authors: Al-Shobaili, Hani A., Robaee, Ahmad A. Al, Alzolibani, Abdullateef A., Rasheed, Zafar
Format: Article
Language:English
Subjects:
Adult
Anti-ROS-CAT antibodies
Autoantibodies - blood
Biomarkers - blood
Catalase - immunology
Catalase - metabolism
Female
Humans
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - physiopathology
Middle Aged
Oxidation-Reduction
Oxidized catalase
Reactive Oxygen Species - metabolism
Severity of Illness Index
SLE
SLEDAI
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Summary:Objectives: This study was undertaken to investigate the status and contribution of oxidized catalase in systemic lupus erythematosus (SLE) and to explore whether oxidized catalase has a role in disease progression. Methods: Catalase (CAT) was modified by reactive oxygen species (ROS). Sera from 50 SLE patients with varying levels of disease activity according to SLE Disease-Activity-Index (SLEDAI) and 45 age- and sex-matched healthy controls were evaluated for antibodies against oxidized CAT. Results: Serum analysis showed significantly higher level of anti-oxidized-CAT-antibodies in SLE patients compared with controls. Interestingly, not only was there an increased number of subjects positive for anti-oxidized-CAT-antibodies, but also the levels of these antibodies were significantly higher among SLE patients, whose SLEDAI scores were ≥10 as compared with lower SLEDAI scores (
ISSN:0882-0139
1532-4311
DOI:10.3109/08820139.2012.751396