Biocompatibility of BioAggregate and mineral trioxide aggregate on the liver and kidney

• Published in: International endodontic journal 2013-08, Vol.46 (8), p.730-737
• Main Authors: Khalil, W. A., Eid, N. F.
• Format: Article
• Language: English
• Subjects: Alanine Transaminase - blood; Aluminum Compounds - toxicity; Animals; Aspartate Aminotransferases - blood; BioAggregate; biocompatibility; Biocompatible Materials - toxicity; Calcium Compounds - toxicity; Calcium Hydroxide - toxicity; Collagen - analysis; Creatinine - blood; Drug Combinations; effect on liver and kidney; grey MTA; Hepatitis, Animal - blood; Hepatitis, Animal - chemically induced; Hydroxyapatites - toxicity; Kidney - drug effects; Kidney - pathology; Kidney Cortex - drug effects; Kidney Cortex - pathology; Kidney Glomerulus - drug effects; Kidney Glomerulus - pathology; Kidney Tubules - drug effects; Kidney Tubules - pathology; Kupffer Cells - drug effects; Kupffer Cells - pathology; Liver - drug effects; Liver - pathology; Male; Nephritis - blood; Nephritis - chemically induced; Oxides - toxicity; Portal Vein - drug effects; Portal Vein - pathology; Random Allocation; Rats; Root Canal Filling Materials - toxicity; Silicates - toxicity; Subcutaneous Tissue - surgery; Time Factors; Urea - blood
• ISSN: 0143-2885; 1365-2591
• DOI: 10.1111/iej.12050

Aim To investigate and compare the systemic toxic effect of DiaRoot BioAggregate and grey ProRoot Mineral trioxide aggregate (MTA) on the liver and kidney after 7 and 30 days. Methodology Forty‐two white albino rats were divided into two main groups. Group (1), considered the control group (n = 18), was further divided into two subgroups. The negative control subgroup (n = 6) received no treatment. The empty tube subgroup (n = 12) received empty sterile Teflon tubes. In Group (2), considered the experimental group (n = 24), the rats were divided equally into two subgroups. One subgroup received MTA, whilst the other received BioAggregate. The materials in the Teflon tubes were implanted subcutaneously in the dorsal side of the rats. Blood samples were taken to investigate the change of kidney and liver functions on day 7 and day 30. The liver and kidney organs were subjected to histopathological examination and calculation of the number of inflammatory cells. Data analysis was performed using one‐way anova with post hoc multiple comparisons with the Tukey's test. Student's t‐test was used to compare the changes in liver and kidney functions amongst the groups. Results On day 7, a significantly more severe inflammatory reaction was observed in both experimental subgroups compared with the control (P