IgG4 Orbital Inflammation in a 5-Year-Old Child Presenting as an Orbital Mass

Abstract IgG4 is a newly known systemic disorder. It can present as orbital inflammation or as an orbital mass. We describe the case of a 5-year-old child with proptosis and globe dystopia who went on to have an orbital biopsy. Initially this was reported to be idiopathic orbital inflammation. After...

Full description

Saved in:
Bibliographic Details
Published in:Orbit (Amsterdam) 2013-04, Vol.32 (2), p.137-140
Main Authors: Kalapesi, Freny Boman, Garrott, Helen Michelle, Moldovan, Corina, Williams, Mandy, Ramanan, Athimalaipet, Herbert, Helen Mary
Format: Article
Language:English
Subjects:
Child, Preschool
Diagnosis, Differential
Drug Therapy, Combination
Female
Humans
Hypergammaglobulinemia - diagnosis
Hypergammaglobulinemia - drug therapy
Hypergammaglobulinemia - immunology
IgG4
Immunoglobulin G - blood
Immunosuppressive Agents - therapeutic use
inflammatory
Magnetic Resonance Imaging
Mycophenolic Acid - analogs & derivatives
Mycophenolic Acid - therapeutic use
Orbital Neoplasms - diagnosis
Orbital Neoplasms - drug therapy
Orbital Neoplasms - immunology
Orbital Pseudotumor - diagnosis
Orbital Pseudotumor - drug therapy
Orbital Pseudotumor - immunology
orbital pseudotumour
Plasma Cells - immunology
Prednisone - therapeutic use
Tomography, X-Ray Computed
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract IgG4 is a newly known systemic disorder. It can present as orbital inflammation or as an orbital mass. We describe the case of a 5-year-old child with proptosis and globe dystopia who went on to have an orbital biopsy. Initially this was reported to be idiopathic orbital inflammation. After IgG4-RD was considered in the differential, the orbital biopsy was revisited, immunohistochemistry was done and the patient's serum was tested for IgG subclass levels. IgG4-RD was diagnosed and the patient was subsequently treated with prednisone and mycophenolate and made a good recovery. This is the youngest reported case of IgG4-RD in a child.
ISSN:0167-6830
1744-5108
DOI:10.3109/01676830.2013.764449