Erythrocyte Omega-6 and Omega-3 Fatty Acids and Mammographic Breast Density

Diets low in omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and high in omega-3 (n-3) PUFAs may protect against breast cancer development. Associations of PUFA intake with mammographic density, an intermediate marker of breast cancer risk, have been inconsistent; however, prior studies have relie...

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Bibliographic Details
Published in:Nutrition and cancer 2013-04, Vol.65 (3), p.410-416
Main Authors: Hudson, Alana G, Reeves, Katherine W, Modugno, Francesmary, Wilson, John W, Evans, Rhobert W, Vogel, Victor G, Gierach, Gretchen L, Simpson, Jennifer, Weissfeld, Joel L
Format: Article
Language:English
Subjects:
Aged
Arachidonic Acid - blood
Body Mass Index
Breast cancer
Breast Density
breast neoplasms
Breast Neoplasms - blood
correlation
diet
Docosahexaenoic Acids - blood
Eicosapentaenoic Acid - blood
Erythrocytes
Erythrocytes - chemistry
Fatty Acids, Omega-3 - blood
Fatty Acids, Omega-6 - blood
Female
gas chromatography
hormones
Humans
linear models
Mammary Glands, Human - abnormalities
Mammography
Menopause
Middle Aged
omega-3 fatty acids
polyunsaturated fatty acids
Postmenopause
risk
Women
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Summary:Diets low in omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and high in omega-3 (n-3) PUFAs may protect against breast cancer development. Associations of PUFA intake with mammographic density, an intermediate marker of breast cancer risk, have been inconsistent; however, prior studies have relied on self-reported dietary PUFA intake. We examined the association between circulating erythrocyte n-6 and n-3 PUFAs with mammographic density in 248 postmenopausal women who were not taking exogenous hormones. PUFAs in erythrocytes were measured by gas-liquid chromatography, and mammographic density was assessed quantitatively by planimetry. Spearman's correlation coefficients and generalized linear models were used to evaluate the relationships between PUFA measures and mammographic density. None of the erythrocyte n-6 or n-3 PUFA measures were associated with percent density or dense breast area.
ISSN:1532-7914
0163-5581
1532-7914
DOI:10.1080/01635581.2013.760744