Experimental induction and oral transmission of avian AA amyloidosis in vaccinated white hens

Abstract Avian AA amyloidosis is commonly observed in adult birds afflicted with bacterial infections or chronic inflammatory disorders. Experimental AA amyloidosis in birds can be induced by repeated inflammatory stimulation, such as injection with casein or vaccination with oil-emulsified bacterin...

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Bibliographic Details
Published in:Amyloid 2013-06, Vol.20 (2), p.80-85
Main Authors: Murakami, Tomoaki, Muhammad, Naeem, Inoshima, Yasuo, Yanai, Tokuma, Goryo, Masanobu, Ishiguro, Naotaka
Format: Article
Language:English
Subjects:
Administration, Oral
Amyloid - administration & dosage
Amyloid - adverse effects
Amyloid A
amyloid enhancing factor
Amyloidosis - etiology
Amyloidosis - pathology
Animals
chicken AA amyloidosis
Chickens - immunology
Chickens - microbiology
Disease Transmission, Infectious
Immunoenzyme Techniques
Mycoplasma gallisepticum - pathogenicity
Mycoplasma Infections - complications
Mycoplasma Infections - microbiology
Mycoplasma Infections - prevention & control
Poultry Diseases - microbiology
Poultry Diseases - prevention & control
Salmonella enteritidis
Salmonella enteritidis - pathogenicity
Salmonella Infections - complications
Salmonella Infections - microbiology
Salmonella Infections - prevention & control
Vaccination
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Summary:Abstract Avian AA amyloidosis is commonly observed in adult birds afflicted with bacterial infections or chronic inflammatory disorders. Experimental AA amyloidosis in birds can be induced by repeated inflammatory stimulation, such as injection with casein or vaccination with oil-emulsified bacterins. However, the transmission of amyloidosis among avian species has not been studied well to date. In the present study, we confirm the potential induction of avian AA amyloidosis by inoculation of Salmonella enteritidis (SE) vaccine or Mycoplasma gallisepticum vaccine. To determine the transmission of chicken AA amyloidosis among white hens, we induced experimental AA amyloidosis in vaccinated chickens by intravenous or oral administration of chicken AA fibrils. Amyloid deposits were observed in chickens injected with SE and inoculated with chicken AA fibrils intravenously (21/26: 81%) and orally (8/12: 67%). These results suggest that chicken AA amyloidosis can be induced by vaccinations, and may be transmitted among like species by oral administration.
ISSN:1350-6129
1744-2818
DOI:10.3109/13506129.2013.783474