Pulmonary Fibrosis Effect of Ammonium Perchlorate Exposure in Rabbit

Ammonium perchlorate (AP) is a kind of inorganic chemical. To evaluate the potential pulmonary fibrosis caused by occupational exposure to this compound, 25 male rabbits were randomly allocated into 5 groups to receive AP or bleomycin or saline by intratracheal injection. All rabbits were sacrificed...

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Bibliographic Details
Published in:Archives of environmental & occupational health 2013-08, Vol.68 (3), p.161-165
Main Authors: Wu, Fenghong, Chen, Hongxia, Zhou, Xuan, Zhang, Rao, Ding, Miaohong, Liu, Qin, Peng, Kai-liang
Format: Article
Language:English
Subjects:
Air Pollutants, Occupational - toxicity
ammonium perchlorate
Animals
Bleomycin - toxicity
collagen
Collagen - metabolism
Disease Models, Animal
Eosine Yellowish-(YS) - metabolism
Fibroblasts - drug effects
Hematoxylin - metabolism
Humans
Intubation, Intratracheal
Lung - cytology
Lung - drug effects
Male
Microscopy, Electron, Transmission
Occupational Diseases - chemically induced
Occupational Diseases - pathology
Perchlorates - toxicity
pulmonary fibrosis
Pulmonary Fibrosis - chemically induced
Pulmonary Fibrosis - pathology
Quaternary Ammonium Compounds - toxicity
Rabbits
Random Allocation
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Summary:Ammonium perchlorate (AP) is a kind of inorganic chemical. To evaluate the potential pulmonary fibrosis caused by occupational exposure to this compound, 25 male rabbits were randomly allocated into 5 groups to receive AP or bleomycin or saline by intratracheal injection. All rabbits were sacrificed and lung tissues were removed to prepare hematoxylin and eosin (HE) staining for microscope observation and to perform electron microscopy examine. In microscope observation, AP-instilled lung tissue showed inflammatory infiltrates, alveolar collapse, subpleural thickening, and lymphocyte proliferation. Electron microscopy examination of lung tissue showed massive fibroblast accumulation, collagen fiber hyperplasia, and dense collagen deposition. The histopathological changes were considered as effective indicator linking to the development of pulmonary fibrosis. These results demonstrated that chronic instillation of AP can induce pulmonary fibrosis. And these results revealed that AP has pulmonary toxic effect.
ISSN:1933-8244
2154-4700
DOI:10.1080/19338244.2012.676105