Diagnostic value of thiols, paraoxonase 1, arylesterase and oxidative balance in colorectal cancer in human

• Published in: Neoplasma 2013, Vol.60 (4), p.419
• Main Authors: Bulbuller, N, Eren, E, Ellidag, H Y, Oner, O Z, Sezer, C, Aydin, O, Yılmaz, N
• Format: Article
• Language: English
• Subjects: Aryldialkylphosphatase - metabolism; Carboxylic Ester Hydrolases - metabolism; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - metabolism; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Reactive Oxygen Species - metabolism; Sulfhydryl Compounds - blood
• ISSN: 0028-2685
• DOI: 10.4149/neo_2013_054

Oxidative stress has been shown to play an important role in carcinogenesis. We hypothesize that serum oxidative and anti-oxidative factors work together to influence colon and rectal cancer through an oxidative balance mechanism. Total thiol (Ttl) is considered a plasma antioxidant and high density lipoprotein (HDL)- dependent paraoxonase l (PON1) is known as a free radical scavenger. This study was undertaken to determine the activity of PON1, arylesterase (ARE) and Ttl levels and oxidative balance in colorectal cancer (CRC) patients and healthy subjects.Paraoxonase and arylesterase activities of the HDL-dependent PON1 enzyme and the level of Ttl, total oxidant status (TOS) ,total antioxidant status (TAS) in forty patients with CRC (19 female, 21 male; mean age, 56.5 ± 2.1) and thirty-nine age and sex matched healthy persons (22 female, 17 male; mean age 56 ± 1.7) were studied.PON1 and ARE activities were significantly lower in patients with CRC compared to controls (p