Comparison of Viral Env Proteins from Acute and Chronic Infections with Subtype C Human Immunodeficiency Virus Type 1 Identifies Differences in Glycosylation and CCR5 Utilization and Suggests a New Strategy for Immunogen Design

• Published in: Journal of Virology 2013-07, Vol.87 (13), p.7218-7233
• Main Authors: Ping, Li-Hua, Joseph, Sarah B, Anderson, Jeffrey A, Abrahams, Melissa-Rose, Salazar-Gonzalez, Jesus F, Kincer, Laura P, Treurnicht, Florette K, Arney, Leslie, Ojeda, Suany, Zhang, Ming, Keys, Jessica, Potter, E Lake, Chu, Haitao, Moore, Penny, Salazar, Maria G, Iyer, Shilpa, Jabara, Cassandra, Kirchherr, Jennifer, Mapanje, Clement, Ngandu, Nobubelo, Seoighe, Cathal, Hoffman, Irving, Gao, Feng, Tang, Yuyang, Labranche, Celia, Lee, Benhur, Saville, Andrew, Vermeulen, Marion, Fiscus, Susan, Morris, Lynn, Karim, Salim Abdool, Haynes, Barton F, Shaw, George M, Korber, Bette T, Hahn, Beatrice H, Cohen, Myron S, Montefiori, David, Williamson, Carolyn, Swanstrom, Ronald
• Format: Article
• Language: English
• Subjects: Antibodies; Base Sequence; Cloning, Molecular; Cluster Analysis; Cohort Studies; Female; Genetic Variation; Glycosylation; HIV Infections - metabolism; HIV Infections - prevention & control; HIV Infections - transmission; HIV-1 - metabolism; Human immunodeficiency virus 1; Humans; Malawi; Male; Molecular Sequence Data; Neutralization Tests; Pathogenesis and Immunity; Phylogeny; Protein Conformation; Receptors, CCR5 - chemistry; Receptors, CCR5 - metabolism; Sequence Alignment; Sequence Analysis, DNA; Sex Factors; South Africa; T-Lymphocytes - immunology; T-Lymphocytes - virology; Viral Envelope Proteins - genetics; Viral Envelope Proteins - metabolism; Virus Replication - physiology
• ISSN: 0022-538X; 1098-5514
• DOI: 10.1128/JVI.03577-12

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