Is AMH useful to reduce low ovarian response to GnRH antagonist protocol in oocyte donors?

Abstract We aimed to establish the reference values of Anti-Müllerian hormone (AMH) in our oocyte donor population and correlate them with the ovarian response to an antagonist stimulation protocol and to study the predictive capacity of AMH for poor response (PR). Normal AMH curves were obtained fo...

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Bibliographic Details
Published in:Gynecological endocrinology 2013-08, Vol.29 (8), p.754-757
Main Authors: Martínez, Francisca, Clua, Elisabet, Carreras, Olga, Tur, Rosa, Rodríguez, Ignacio, Barri, Pere N.
Format: Article
Language:English
Subjects:
Adolescent
Adult
AMH
Anti-Mullerian Hormone - blood
Anti-Mullerian Hormone - physiology
Biomarkers, Pharmacological - blood
Female
Fertility Agents, Female - therapeutic use
GnRH antagonist
Gonadotropin-Releasing Hormone - antagonists & inhibitors
Hormone Antagonists - therapeutic use
Humans
Oocyte Donation - methods
Oocyte Donation - statistics & numerical data
oocyte donor
Oocyte Retrieval - statistics & numerical data
ovarian response
Ovulation - blood
Ovulation - drug effects
Ovulation Induction - methods
poor ovarian response
Predictive Value of Tests
Sensitivity and Specificity
Treatment Outcome
Young Adult
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Summary:Abstract We aimed to establish the reference values of Anti-Müllerian hormone (AMH) in our oocyte donor population and correlate them with the ovarian response to an antagonist stimulation protocol and to study the predictive capacity of AMH for poor response (PR). Normal AMH curves were obtained for 172 candidates. AMH levels decreased with age although they showed great heterogeneity and spread in absolute values at any age range. AMH levels showed a positive correlation, statistically significant, with the Antral Follicle Count (r = 0,705), and number of oocytes retrieved (r = 0,356). In receiver operating characteristic curve analysis a threshold value of AMH = 2.31 ng/ml predictive for retrieval
ISSN:0951-3590
1473-0766
DOI:10.3109/09513590.2013.801443