Lanthanide-doped luminescent nanoprobes: controlled synthesis, optical spectroscopy, and bioapplications

Lanthanide-doped inorganic nanoparticles possess superior physicochemical features such as long-lived luminescence, large antenna-generated Stokes or anti-Stokes shifts, narrow emission bands, high resistance to photobleaching and low toxicity, and thus are regarded as a new generation of luminescen...

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Bibliographic Details
Published in:Chemical Society reviews 2013-01, Vol.42 (16), p.6924-6958
Main Authors: Liu, Yongsheng, Tu, Datao, Zhu, Haomiao, Chen, Xueyuan
Format: Article
Language:English
Subjects:
Antennas
Lanthanoid Series Elements - chemistry
Luminescent Measurements
Medical imaging
Metal Nanoparticles - chemistry
Nanoparticles
Nanostructure
Oxides - chemistry
Semiconductors
Spectroscopy
Synthesis (chemistry)
Toxicity
Transistors, Electronic
Tumors
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Summary:Lanthanide-doped inorganic nanoparticles possess superior physicochemical features such as long-lived luminescence, large antenna-generated Stokes or anti-Stokes shifts, narrow emission bands, high resistance to photobleaching and low toxicity, and thus are regarded as a new generation of luminescent bioprobes as compared to conventional molecular probes like organic dyes and lanthanide chelates. These functional nanoparticles, although most of their bulk counterparts were well studied previously, have attracted renewed interest for their biomedical applications in areas as diverse as biodetection, bioimaging, and disease diagnosis and therapeutics. In this review, we provide a comprehensive survey of the latest advances made in developing lanthanide-doped inorganic nanoparticles as potential luminescent bioprobes, which covers areas from their fundamental chemical and physical features to bioapplications including controlled synthesis methodology, surface modification chemistry, optical spectroscopy, and their promising applications in diverse fields, with an emphasis on heterogeneous and homogeneous in vitro biodetection of tumor markers and multimodal bioimaging of various tumor tissues. Some future prospects and challenges in this rapidly growing field are also summarized. The latest advances in lanthanide-doped luminescent nano-bioprobes were comprehensively reviewed, from their fundamental chemical and physical features to diverse bioapplications.
ISSN:0306-0012
1460-4744
DOI:10.1039/c3cs60060b