The luminal connection: From animal development to lumopathies

Interconnection of epithelial tubules is a crucial process during organogenesis. Organisms have evolved sets of molecular and cellular strategies to generate an interconnected tubular network during animal development. Spatiotemporal control of common cellular strategies includes dissolution of the...

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Bibliographic Details
Published in:Organogenesis 2013-04, Vol.9 (2), p.111-117
Main Author: Kao, Robert M.
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Basement Membrane - metabolism
Epithelium - growth & development
Epithelium - pathology
Growth and Development
Humans
Intercellular Junctions - pathology
invasive behavior
juxtaposition
kidney
luminal interconnection
lumopathies
Review
Spatio-Temporal Analysis
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Summary:Interconnection of epithelial tubules is a crucial process during organogenesis. Organisms have evolved sets of molecular and cellular strategies to generate an interconnected tubular network during animal development. Spatiotemporal control of common cellular strategies includes dissolution of the basement membrane, apoptosis, rearrangements of cell adhesion junctions, and mesenchymal-like invasive cellular behaviors prior to tubular interconnection. Different model systems exhibit varying degrees of active invasive-like behaviors that precede tubular interconnection, which may reflect changes in cell polarity or differential adhesive cell states. Studies in this newly-emerging field of tubular interconnections will provide a greater understanding of pediatric diseases and cancer metastasis, as well as generate fundamentally new insights into lumen formation pathology, or lumopathies.
ISSN:1547-6278
1555-8592
DOI:10.4161/org.25225