Importance of helper T-cell activation in dendritic cell-based anticancer immunotherapy

Dendritic cell-based anticancer immunotherapy is feasible, safe and results in the induction of tumor-specific immune responses, at least in a fraction of vaccinated patients. The concomitant activation of cytotoxic and helper T cells, by loading DCs with peptides or electroporating them with the co...

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Bibliographic Details
Published in:Oncoimmunology 2013-06, Vol.2 (6), p.e24440-e24440
Main Authors: Schreibelt, Gerty, Bol, Kalijn F., Aarntzen, Erik HJG, Gerritsen, Winald R, Punt, Cornelis JA, Figdor, Carl G, de Vries, I Jolanda M
Format: Article
Language:English
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cancer immunotherapy
dendritic cell vaccination
helper T cells
metastatic melanoma
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Summary:Dendritic cell-based anticancer immunotherapy is feasible, safe and results in the induction of tumor-specific immune responses, at least in a fraction of vaccinated patients. The concomitant activation of cytotoxic and helper T cells, by loading DCs with peptides or electroporating them with the corresponding mRNAs, may further enhance vaccine-induced antitumor responses.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/onci.24440