Assessing intrarenal nonperfusion and vascular leakage in acute kidney injury with multinuclear (1) H/(19) F MRI and perfluorocarbon nanoparticles

We sought to develop a unique sensor-reporter approach for functional kidney imaging that employs circulating perfluorocarbon nanoparticles and multinuclear (1) H/(19) F MRI. (19) F spin density weighted and T1 weighted images were used to generate quantitative functional mappings of both healthy an...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2014-06, Vol.71 (6), p.2186
Main Authors: Hu, Lingzhi, Chen, Junjie, Yang, Xiaoxia, Senpan, Angana, Allen, John S, Yanaba, Noriko, Caruthers, Shelton D, Lanza, Gregory M, Hammerman, Marc R, Wickline, Samuel A
Format: Article
Language:English
Subjects:
Acute Kidney Injury - pathology
Animals
Blood Volume
Calibration
Fluorine
Fluorocarbons - chemical synthesis
Kidney - blood supply
Magnetic Resonance Imaging - methods
Mice
Mice, Inbred C57BL
Nanoparticles
Oxygen - blood
Phantoms, Imaging
Reperfusion Injury - pathology
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Summary:We sought to develop a unique sensor-reporter approach for functional kidney imaging that employs circulating perfluorocarbon nanoparticles and multinuclear (1) H/(19) F MRI. (19) F spin density weighted and T1 weighted images were used to generate quantitative functional mappings of both healthy and ischemia-reperfusion (acute kidney injury) injured mouse kidneys. (1) H blood-oxygenation-level-dependent (BOLD) MRI was also employed as a supplementary approach to facilitate the comprehensive analysis of renal circulation and its pathological changes in acute kidney injury. Heterogeneous blood volume distributions and intrarenal oxygenation gradients were confirmed in healthy kidneys by (19) F MRI. In a mouse model of acute kidney injury, (19) F MRI, in conjunction with blood-oxygenation-level-dependent MRI, sensitively delineated renal vascular damage and recovery. In the cortico-medullary junction region, we observed 25% lower (19) F signal (P 
ISSN:1522-2594
DOI:10.1002/mrm.24851