Efficacy and safety of percutaneous microwave coagulation therapy followed by 125 I seed brachytherapy for VX2 hepatic tumors in a rabbit model

The aim of this study was to evaluate the efficacy and safety of percutaneous microwave coagulation therapy (PMCT) followed by I seed brachytherapy for VX2 liver cancer in rabbits. Eighty New Zealand rabbits were injected with suspensions of VX2 tumor cells to create an animal model. The rabbits wer...

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Published in:Experimental and therapeutic medicine 2013-07, Vol.6 (1), p.159
Main Authors: Yu, Dong-Sheng, Chang, Hong, Sommer, Christof-Matthias, Qu, Wei-Li, Xu, Wen-Jian, Yang, Ren-Jie, Zhao, Peng
Format: Article
Language:English
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Summary:The aim of this study was to evaluate the efficacy and safety of percutaneous microwave coagulation therapy (PMCT) followed by I seed brachytherapy for VX2 liver cancer in rabbits. Eighty New Zealand rabbits were injected with suspensions of VX2 tumor cells to create an animal model. The rabbits were randomly divided into 4 groups (n=20); the control, PMCT, I seed brachytherapy and combination groups. Group A was treated with PMCT at 40 W for 120 sec, group B was treated with I seed brachytherapy and group C was treated with PMCT followed by I seed brachytherapy. Group D were not treated and served as the control group. At 21 days after treatment, the rabbits were sacrificed for pathological assessment. The complete tumor necrosis rate was 19 out of 20 tumors (95%) in group C, 6 (30%) in group A, 0 (0%) in group B and 0 (0%) in the control group. The complete tumor necrosis rate was observed to be significantly different between groups C and A, and between groups C and B (P
ISSN:1792-0981