Normative concentrations of urine thiocyanate in cassava eating communities in Nigeria

Abstract Exposure to cyanide is a major public health problem where highly cyanogenic cassava foods are consumed. Thiocyanate (SCN), the biomarker of exposure to cyanide is present in several foods, and produced endogenously. Concentrations of urine SCN were measured in endemic and non-endemic areas...

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Bibliographic Details
Published in:International journal of food sciences and nutrition 2013-12, Vol.64 (8), p.1036-1041
Main Authors: Oluwole, O. S. A., Oludiran, A. O.
Format: Article
Language:English
Subjects:
Biomarkers
Biomarkers - urine
Cassava
Chemical compounds
Child
cyanide
Cyanides - administration & dosage
Cyanides - adverse effects
Cyanides - urine
Diet
Eating
Ecology
Endemic Diseases
Feeding Behavior
Female
Food science
Human exposure
Humans
Male
Manihot - chemistry
Nigeria
Nigeria - epidemiology
normative
Nutrition research
Plant Extracts - administration & dosage
Plant Extracts - adverse effects
Plant Extracts - urine
Polyneuropathies - chemically induced
Polyneuropathies - epidemiology
polyneuropathy
Reference Values
thiocyanate
Thiocyanates - urine
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Summary:Abstract Exposure to cyanide is a major public health problem where highly cyanogenic cassava foods are consumed. Thiocyanate (SCN), the biomarker of exposure to cyanide is present in several foods, and produced endogenously. Concentrations of urine SCN were measured in endemic and non-endemic areas of ataxic polyneuropathy in Nigeria. Cassava food consumption in the endemic area was twice that of non-endemic areas. Geometrical mean (95% CI) urine SCN was 20 µmol/l (18-24) for no consumption of cassava foods, 56 µmol/l (49-64) for daily consumption, 56 µmol/l (48-65) for twice daily consumption and 85 µmol/l (62-117) for thrice daily consumption. 95th percentile reference limit was 125 µmol/l for no consumption of cassava food, but 360 µmol/l for thrice daily consumption. Urine SCN is a useful biomarker of exposure to cyanide from cassava foods. There is strong ecological association of exposure to cyanide and endemicity of ataxic polyneuropathy.
ISSN:0963-7486
1465-3478
DOI:10.3109/09637486.2013.825697