Loading…
A parallel group double-blind RCT of vitamin D3 assessing physical function: is the biochemical response to treatment affected by overweight and obesity?
Summary Vitamin D may affect skeletal muscle function. In a double-blind, randomised, placebo-controlled trial, we found that vitamin D 3 supplementation (400 or 1,000 I.U. vs. placebo daily for 1 year with bimonthly study visits) does not improve grip strength or reduce falls. Introduction This stu...
Saved in:
Published in: | Osteoporosis international 2014, Vol.25 (1), p.305-315 |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Summary
Vitamin D may affect skeletal muscle function. In a double-blind, randomised, placebo-controlled trial, we found that vitamin D
3
supplementation (400 or 1,000 I.U. vs. placebo daily for 1 year with bimonthly study visits) does not improve grip strength or reduce falls.
Introduction
This study aimed to test the supplementation effects of vitamin D
3
on physical function and examine associations between overweight/obesity and the biochemical response to treatment.
Methods
In a parallel group double-blind RCT, healthy postmenopausal women from North East Scotland (latitude—57° N) aged 60–70 years (body mass index (BMI), 18–45 kg/m
2
) were assigned (computer randomisation) to daily vitamin D
3
(400 I.U. (
n
= 102)/1,000 I.U. (
n
= 101)) or matching placebo (
n
= 102) (97, 96 and 100 participants analysed for outcomes, respectively) from identical coded containers for 1 year. Grip strength (primary outcome), falls, diet, physical activity and ultraviolet B radiation exposure were measured bimonthly, as were serum 25(OH)D, adjusted calcium (ACa) and phosphate. Fat/lean mass (dual energy X-ray absorptiometry), anthropometry, 1,25-dihydroxyvitamin D and parathyroid hormone were measured at baseline and 12 months. Participants and researchers were blinded throughout intervention and analysis.
Results
Treatment had no effect on grip strength (mean change (SD)/year = −0.5 (2.5), −0.9 (2.7) and −0.4 (3.3) kg force for 400/1,000 I.U. vitamin D
3
and placebo groups, respectively (
P
= .10, ANOVA)) or falls (
P
= .65, chi-squared test). Biochemical responses were similar across BMI categories ( |
---|---|
ISSN: | 0937-941X 1433-2965 |
DOI: | 10.1007/s00198-013-2473-8 |