Recent progress in the development of near-infrared fluorescent probes for bioimaging applications

Near-infrared (NIR) fluorescent dyes have emerged as promising modalities for monitoring the levels of various biologically relevant species in cells and organisms. The use of NIR probes enables deep photon penetration in tissue, minimizes photo-damage to biological samples, and produces low backgro...

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Bibliographic Details
Published in:Chemical Society reviews 2014-01, Vol.43 (1), p.16-29
Main Authors: Guo, Zhiqian, Park, Sookil, Yoon, Juyoung, Shin, Injae
Format: Article
Language:English
Subjects:
Biomolecules
Copper - analysis
Design engineering
Enzymes - analysis
Fluorescence
Fluorescence Resonance Energy Transfer - methods
Fluorescent Dyes - chemistry
Foaming agents
Hydrogen-Ion Concentration
Mercury - analysis
Molecular Imaging - methods
Monitoring
Nanostructures
Organisms
Penetration
Peroxynitrous Acid - analysis
Photons
Reactive Oxygen Species - analysis
Spectroscopy, Near-Infrared - methods
Sulfhydryl Compounds - analysis
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Summary:Near-infrared (NIR) fluorescent dyes have emerged as promising modalities for monitoring the levels of various biologically relevant species in cells and organisms. The use of NIR probes enables deep photon penetration in tissue, minimizes photo-damage to biological samples, and produces low background auto-fluorescence from biomolecules present in living systems. The number of new analyte-responsive NIR fluorescent probes has increased substantially in recent years as a consequence of intense research efforts. In this tutorial review, we highlight recent advances (2010-2013) made in the development and applications of NIR fluorescent probes. The review focuses on NIR fluorescent probes that have been devised to sense various biologically important species, including ROS/RNS, metal ions, anions, enzymes and other related species, as well as intracellular pH changes. The basic principles involved in the design of functional NIR fluorescent probes and suggestions about how to expand applications of NIR imaging agents are also described. The review focuses on NIR fluorescent probes that have been devised to sense various biologically important species.
ISSN:0306-0012
1460-4744
DOI:10.1039/c3cs60271k