The STAT3-DNMT1 connection

Gene activity is regulated by transcriptional and epigenetic mechanisms. A paper in 2005 by Zhang et al. 1 showed that STAT3 binds to the DNA methyl transferase, DNMT1 and their data indicated that STAT3 may cause epigenetic gene silencing by targeting DNMT1 to the PTPN6 promoter. Now, a paper by Le...

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Bibliographic Details
Published in:JAK-STAT 2012-10, Vol.1 (4), p.257-260
Main Author: Thomas, N. Shaun B.
Format: Article
Language:English
Subjects:
acetylation
cancer
DNA methylation
DNMT1
epigenetics
STAT3
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Summary:Gene activity is regulated by transcriptional and epigenetic mechanisms. A paper in 2005 by Zhang et al. 1 showed that STAT3 binds to the DNA methyl transferase, DNMT1 and their data indicated that STAT3 may cause epigenetic gene silencing by targeting DNMT1 to the PTPN6 promoter. Now, a paper by Lee et al. 2 has fleshed out the mechanism. They provide evidence that acetylation of STAT3 regulates the binding of DNMT1, CpG DNA methylation and regulation of several genes, including that encoding the estrogen receptor α (ESR1) in breast cancer cells.
ISSN:2162-3988
2162-3996
2162-3996
DOI:10.4161/jkst.22436