Oxidative stress status in patients with melasma

Abstract Background: Melasma is an acquired skin disease characterized clinically by development of gray-brown macules or patches. The lesions have geographic borders and most often seen on face and less frequently on the neck and forearms. Pathogenesis has not been completely understood yet. Althou...

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Published in:Cutaneous and ocular toxicology 2014-09, Vol.33 (3), p.212-217
Main Authors: Seçkin, Havva Y ld z, Kalkan, Göknur, Ba, Yalç n, Akba, Ali, Önder, Yalç n, Özyurt, Hüseyin, ahin, Mehmet
Format: Article
Language:English
Subjects:
Adult
Anti-oxidant enzymes
Case-Control Studies
Female
Glutathione Peroxidase - blood
Humans
Male
Malondialdehyde - blood
Melanosis - blood
Melanosis - epidemiology
melasma
Nitric Oxide - blood
Oxidative Stress
Protein Carbonylation
Superoxide Dismutase - blood
Thiobarbituric Acid Reactive Substances - metabolism
Turkey - epidemiology
Young Adult
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Summary:Abstract Background: Melasma is an acquired skin disease characterized clinically by development of gray-brown macules or patches. The lesions have geographic borders and most often seen on face and less frequently on the neck and forearms. Pathogenesis has not been completely understood yet. Although the disease constitutes a very disturbing cosmetic problem, it has not obtained an efficient treatment. There were not any studies in the literature that evaluates the role of oxidative stress in melasma. Objectives: The evaluation of the role of oxidative stress in melasma. Methods: Fifty melasma patients and 50 healthy volunteers were included in the study. The diagnosis was made clinically and the patients were evaluated by Melasma Area Severity Index. Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) enzyme activities and malondialdehyde, nitric oxide, protein carbonyl levels were measured both in the melasma group and the control group. Results: SOD and GSH-Px enzyme activities were significantly higher in the patient group in comparison with the control group (p 
ISSN:1556-9527
1556-9535
DOI:10.3109/15569527.2013.834496