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Unusual ECD fragmentation attributed to gas-phase helix formation in a conformationally dynamic peptide
The helix-forming character of a model decapeptide, L 4 PL 4 K, is determined in the absence of solvent using ion mobility mass spectrometry, electron capture dissociation and molecular mechanics simulations. Unusual ECD fragmentation patterns dominated by b ions are attributed to helix formation up...
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Published in: | Chemical communications (Cambridge, England) England), 2014-01, Vol.5 (2), p.198-2 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The helix-forming character of a model decapeptide, L
4
PL
4
K, is determined in the absence of solvent using ion mobility mass spectrometry, electron capture dissociation and molecular mechanics simulations. Unusual ECD fragmentation patterns dominated by
b
ions are attributed to helix formation upon electron capture and as a signature of conformational dynamics.
The helix-forming character of a model decapeptide, is determined with IM-MS, ECD, and MD simulations. Unusual ECD fragmentation patterns dominated by
b
ions are attributed to helix formation upon electron capture presenting a signature for conformational dynamics. |
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ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/c3cc46356g |