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Unusual ECD fragmentation attributed to gas-phase helix formation in a conformationally dynamic peptide

The helix-forming character of a model decapeptide, L 4 PL 4 K, is determined in the absence of solvent using ion mobility mass spectrometry, electron capture dissociation and molecular mechanics simulations. Unusual ECD fragmentation patterns dominated by b ions are attributed to helix formation up...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-01, Vol.5 (2), p.198-2
Main Authors: Kalapothakis, Jason M. D, Berezovskaya, Yana, Zampronio, Cleidiane G, Faull, Peter A, Barran, Perdita E, Cooper, Helen J
Format: Article
Language:English
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Summary:The helix-forming character of a model decapeptide, L 4 PL 4 K, is determined in the absence of solvent using ion mobility mass spectrometry, electron capture dissociation and molecular mechanics simulations. Unusual ECD fragmentation patterns dominated by b ions are attributed to helix formation upon electron capture and as a signature of conformational dynamics. The helix-forming character of a model decapeptide, is determined with IM-MS, ECD, and MD simulations. Unusual ECD fragmentation patterns dominated by b ions are attributed to helix formation upon electron capture presenting a signature for conformational dynamics.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc46356g