Osteogenetic property of a biodegradable three-dimensional macroporous hydrogel coating on titanium implants fabricated via EPD

The potential for a successful integration of implants with surrounding tissue may be jeopardized in a number of compromised conditions. Biochemical surface modification is one of the choices to extend the spectrum of indications. We have previously successfully fabricated chitosan-gelatin (CS G) co...

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Bibliographic Details
Published in:Biomedical materials (Bristol) 2014-02, Vol.9 (1), p.015008-015008
Main Authors: Ma, Kena, Cai, Xinjie, Zhou, Yi, Zhang, Zhen, Jiang, Tao, Wang, Yining
Format: Article
Language:English
Subjects:
3T3 Cells
Alkaline Phosphatase - chemistry
Animals
Bone and Bones
Chitosan - chemistry
chitosan-gelatin coatings
Coated Materials, Biocompatible - chemistry
electrophoretic deposition
Gelatin - chemistry
Hydrogels - chemistry
implant
Male
Mice
Muramidase - chemistry
Osseointegration
osteogenesis
Osteogenesis - physiology
Porosity
Prostheses and Implants
Rabbits
scaffold
Surface Properties
Titanium - chemistry
X-Ray Microtomography
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Summary:The potential for a successful integration of implants with surrounding tissue may be jeopardized in a number of compromised conditions. Biochemical surface modification is one of the choices to extend the spectrum of indications. We have previously successfully fabricated chitosan-gelatin (CS G) coatings on a titanium surface via electrophoretic deposition, which may be promising candidates for further loading of functional agents. In this study, we have identified the microstructure, physicochemical properties and biological performance of CS G coatings in vitro and in vivo. The in vitro degradation test indicated that CS G coatings in the presence of lysozyme showed a significant weight loss after 28 days. The results of the cell culture exhibited that CS G coatings could sustain MC3T3-E1 cell attachment, proliferation and migration. In vivo osteogenetic behavior evaluated by Micro-CT and histomorphometrical analysis revealed significant new bone formation around CS G implants at 8 and 12 weeks, compared to sandblasted acid-etched implants. Moreover, histological evaluation suggested the majority of CS G coatings were degraded at 12 weeks. Therefore, we have concluded that the three-dimensional porous structure of scaffold-like CS G coatings may facilitate osteogenesis and that such coatings can be biodegraded in the early bone healing process.
ISSN:1748-6041
1748-605X
DOI:10.1088/1748-6041/9/1/015008