JAK-STAT3 and somatic cell reprogramming

Reprogramming somatic cells to pluripotency, especially by the induced pluripotent stem cell (iPSC) technology, has become widely used today to generate various types of stem cells for research and for regenerative medicine. However the mechanism(s) of reprogramming still need detailed elucidation,...

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Bibliographic Details
Published in:JAK-STAT 2013-10, Vol.2 (4), p.e24935-e24935
Main Authors: Tang, Yong, Tian, Xiuchun (Cindy)
Format: Article
Language:English
Subjects:
embryonic stem cells
epigenetics
iPSC
JAK
LIF
reprogramming
Review
STAT3
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Summary:Reprogramming somatic cells to pluripotency, especially by the induced pluripotent stem cell (iPSC) technology, has become widely used today to generate various types of stem cells for research and for regenerative medicine. However the mechanism(s) of reprogramming still need detailed elucidation, including the roles played by the leukemia inhibitory factor (LIF) signaling pathway. LIF is central in maintaining the ground state pluripotency of mouse embryonic stem cells (ESCs) and iPSCs by activating the Janus kinase-signal transducer and activator of transcription 3 (JAK-STAT3) pathway. Characterizing and understanding this pathway holds the key to generate naïve pluripotent human iPSCs which will facilitate the development of patient-specific stem cell therapy. Here we review the historical and recent developments on how LIF signaling pathway regulates ESC pluripotency maintenance and somatic cell reprogramming, with a focus on JAK-STAT3.
ISSN:2162-3988
2162-3996
2162-3996
DOI:10.4161/jkst.24935