Novel vitamin D compounds and skin cancer prevention

As skin cancer is one of the most costly health issues in many countries, particularly in Australia, the possibility that vitamin D compounds might contribute to prevention of this disease is becoming increasingly more attractive to researchers and health communities. In this article, important epid...

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Bibliographic Details
Published in:Dermato-endocrinology 2013-01, Vol.5 (1), p.20-33
Main Authors: Tongkao-on, Wannit, Gordon-Thomson, Clare, Dixon, Katie M., Song, Eric J., Luu, Tan, Carter, Sally E., Sequeira, Vanessa B., Reeve, Vivienne E., Mason, Rebecca S.
Format: Article
Language:English
Subjects:
1α,25-dihydroxyvitaminD
bufalin
Disease prevention
DNA damage
Epidemiology
photocarcinogenesis
photoimmune suppression
photoprotection
Review
Skin cancer
skin cancer prevention
Vitamin D
vitamin D compounds
vitamin D photoproducts
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Summary:As skin cancer is one of the most costly health issues in many countries, particularly in Australia, the possibility that vitamin D compounds might contribute to prevention of this disease is becoming increasingly more attractive to researchers and health communities. In this article, important epidemiologic, mechanistic and experimental data supporting the chemopreventive potential of several vitamin D-related compounds are explored. Evidence of photoprotection by the active hormone, 1α,25dihydroxyvitamin D 3, as well as a derivative of an over-irradiation product, lumisterol, a fluorinated analog and bufalin, a potential vitamin D-like compound, are provided. The aim of this article is to understand how vitamin D compounds contribute to UV adaptation and potentially, skin cancer prevention.
ISSN:1938-1972
1938-1980
1938-1980
DOI:10.4161/derm.23939