Quality of life and psychosocial issues are important outcome measures in eczema treatment

Abstract Background: Atopic eczema (AE) is a common relapsing inflammatory skin disease in children associated with chronicity and poor quality of life. Many children also display depressive, anxiety and stress symptoms. Aim: To investigate the prevalence of depressive, anxiety and stress symptoms,...

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Bibliographic Details
Published in:The Journal of dermatological treatment 2015-02, Vol.26 (1), p.83-89
Main Authors: Hon, Kam Lun, Pong, N. H., Poon, Terence C. W., Chan, Dorothy F. Y., Leung, T. F., Lai, Kelly Y. C., Wing, Y. K., Luk, Nai Ming
Format: Article
Language:English
Subjects:
Adolescent
Anxiety
Anxiety - epidemiology
Anxiety - etiology
depression
Depression - epidemiology
Depression - etiology
Dermatitis, Atopic - pathology
Dermatitis, Atopic - psychology
Dermatitis, Atopic - therapy
eczema
Female
Glucocorticoids - therapeutic use
Humans
Male
Outcome Assessment (Health Care) - methods
Prevalence
psychosocial symptoms
Quality of Life
Severity of Illness Index
skin hydration
stress
transepidermal water loss
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Summary:Abstract Background: Atopic eczema (AE) is a common relapsing inflammatory skin disease in children associated with chronicity and poor quality of life. Many children also display depressive, anxiety and stress symptoms. Aim: To investigate the prevalence of depressive, anxiety and stress symptoms, and if these symptoms are associated with disease severity, quality of life and skin biophysiology in childhood AE. Methods: Psychological symptoms, eczema severity, quality of life and biophysical skin condition of consecutive adolescents at the pediatric dermatology clinic of a teaching hospital were evaluated with the validated Chinese versions of Depressive, Anxiety, Stress Scales (DASS-42), Beck Depression Inventory (BDI-13), Nottingham Eczema Severity Score (NESS), Children's Dermatology Life Quality Index (CDLQI), transepidermal water loss (TEWL) and stratum corneum skin hydration (SH), respectively. Results: AE patients (n = 120) had lower SH, higher TEWL, worse CDLQI and reported higher overall, depressive and stress symptom scores, personal history of atopy, current topical corticosteroid usage and food avoidance than non-AE patients (n = 26). Depressive, anxiety and stress symptoms were reported in 21%, 33% and 23% of AE patients, respectively. Multivariate analyses showed that these symptoms were significantly correlated with a poor quality of life (partial correlations of 0.40-0.49; p 
ISSN:0954-6634
1471-1753
DOI:10.3109/09546634.2013.873762