Non-viral gene therapy for bone tissue engineering

The possibilities of using gene therapy for bone regeneration have been extensively investigated. Improvements in the design of new transfection agents, combining vectors and delivery/release systems to diminish cytotoxicity and increase transfection efficiencies have led to several successful in vi...

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Bibliographic Details
Published in:Biotechnology & genetic engineering reviews 2013-01, Vol.29 (2), p.206-220
Main Authors: Wegman, Fiona, Öner, F. Cumhur, Dhert, Wouter J.A., Alblas, Jacqueline
Format: Article
Language:English
Subjects:
bone
Bone Regeneration - genetics
Cell Differentiation - genetics
gene activated matrix
gene therapy
Gene Transfer Techniques
Genetic Therapy
Genetic Vectors
Humans
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - metabolism
multipotent stromal cell (MSC)
non-viral
Osteogenesis - genetics
osteogenicity
Tissue Engineering
Transfection - methods
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Summary:The possibilities of using gene therapy for bone regeneration have been extensively investigated. Improvements in the design of new transfection agents, combining vectors and delivery/release systems to diminish cytotoxicity and increase transfection efficiencies have led to several successful in vitro, ex vivo and in vivo strategies. These include growth factor or short interfering ribonucleic acid (siRNA) delivery, or even enzyme replacement therapies, and have led to increased osteogenic differentiation and bone formation in vivo. These results provide optimism to consider use in humans with some of these gene-delivery strategies in the near future.
ISSN:0264-8725
2046-5556
DOI:10.1080/02648725.2013.801227