Atopy in children with systemic onset juvenile idiopathic arthritis (SoJIA) is associated with a worse outcome

Abstract Context: Atopy and systemic onset juvenile idiopathic arthritis (SoJIA) are two potential outcomes of a dysregulated immune system. Although rare, SoJIA causes 60% of the morbidity of JIA patients which exhibit a wide heterogeneity of prognosis and treatment. Co-morbidities can complicate t...

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Published in:Immunopharmacology and immunotoxicology 2014-04, Vol.36 (2), p.176-181
Main Authors: Zhang, Wen-Ming, Xu, Ling-Yun, Lu, Yan-ming, Cao, Lan-Fang
Format: Article
Language:English
Subjects:
Arthritis, Juvenile - pathology
Atopy
autoimmunity prognosis
Child
Female
Humans
infection
Male
Prognosis
Prospective Studies
risk factor
systemic onset juvenile idiopathic arthritis
Treatment Outcome
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Summary:Abstract Context: Atopy and systemic onset juvenile idiopathic arthritis (SoJIA) are two potential outcomes of a dysregulated immune system. Although rare, SoJIA causes 60% of the morbidity of JIA patients which exhibit a wide heterogeneity of prognosis and treatment. Co-morbidities can complicate the responses to therapy. Objective: To study the influence of co-existing atopy on the prognosis of SoJIA. Materials and Methods: Patients diagnosed with SoJIA between Jan 2006 and Sep 2010 were screened, enrolled in this prospective cohort study, and followed for 2 years. Management of SoJIA patients was assessed by ACR Pedi30/50/70 criteria, laboratory variables, and systemic feature score. Results: At disease onset, 61 SoJIA patients (34 male and 27 female) were enrolled and were divided into SoJIA patients with atopy (n = 27) or those without atopy (n = 34). Atopic group at disease onset had significantly higher numbers of affected joints, ferritin levels and IgE serum levels than the non-atopic group. At 3 and 6 months, fewer SoJIA patients with atopy reached the ACR Pedi50 criteria (p 
ISSN:0892-3973
1532-2513
DOI:10.3109/08923973.2014.898068