A multicomponent approach to the synthesis of N-sulfonyl β(2,3)-amino esters

The multicomponent synthesis of α,β-disubstituted N-sulfonyl β-amino esters is described. It involves a zinc-mediated, cobalt-catalyzed three-component reaction between sulfonylimines, acrylates and organic bromides. A possible mechanism is proposed, emphasizing the intermediate formation of an orga...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2014-06, Vol.12 (21), p.3423
Main Authors: Le Gall, Erwan, Sengmany, Stéphane, Samb, Issa, Benakrour, Sabrina, Colin, Christopher, Pignon, Antoine, Léonel, Eric
Format: Article
Language:English
Online Access:Get full text
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Summary:The multicomponent synthesis of α,β-disubstituted N-sulfonyl β-amino esters is described. It involves a zinc-mediated, cobalt-catalyzed three-component reaction between sulfonylimines, acrylates and organic bromides. A possible mechanism is proposed, emphasizing the intermediate formation of an organocobalt as the initiator of a Mannich-like process.
ISSN:1477-0539
DOI:10.1039/c3ob42353k