A Case-Control Review of Placentas from Patients with Intrahepatic Cholestasis of Pregnancy

Objective: To compare the incidence of histopathological features in placentas from women with cholestasis of pregnancy to healthy individuals without ICP. Methods: Placentas from mothers with and without cholestasis of pregnancy were reviewed by a pathologist masked to the study group. Subjects wer...

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Bibliographic Details
Published in:Fetal and pediatric pathology 2014-08, Vol.33 (4), p.210-215
Main Authors: Patel, Shivani, Pinheiro, Meaghan, Felix, Juan C., Opper, Neisha, Ouzounian, Joseph G., Lee, Richard H.
Format: Article
Language:English
Subjects:
Adult
Anti-Inflammatory Agents - pharmacology
Case-Control Studies
cholestasis
Cholestasis, Intrahepatic - drug therapy
Cholestasis, Intrahepatic - pathology
Chorionic Villi - pathology
Female
Humans
Infant, Newborn
intrahepatic
placenta
Placenta - drug effects
Placenta - pathology
Placenta Diseases - pathology
Placenta Diseases - prevention & control
Pregnancy
Pregnancy Complications - drug therapy
Pregnancy Complications - pathology
ursodeoxycholic acid
Ursodeoxycholic Acid - therapeutic use
Young Adult
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Summary:Objective: To compare the incidence of histopathological features in placentas from women with cholestasis of pregnancy to healthy individuals without ICP. Methods: Placentas from mothers with and without cholestasis of pregnancy were reviewed by a pathologist masked to the study group. Subjects were excluded if they had medical problems already associated with placental histopathology. Results: Twenty-four cases and 30 controls placentas were reviewed. Seventeen placental histopathological features were found. There was no statistically significant difference between the groups. Amongst patients with cholestasis, there was a decrease in villitis of unknown etiology in those treated with ursodeoxycholic acid. Conclusion: There is no difference in the placental histopathology in cholestasis of pregnancy compared to normal pregnancies, but treatment of patients with cholestasis of pregnancy with ursodeoxycholic acid may decrease findings of villitis of unknown etiology.
ISSN:1551-3815
1551-3823
DOI:10.3109/15513815.2014.899413