Stamping surface-enhanced Raman spectroscopy for label-free, multiplexed, molecular sensing and imaging

We report stamping surface-enhanced Raman spectroscopy (S-SERS) for label-free, multiplexed, molecular sensing and large-area, high-resolution molecular imaging on a flexible, nonplasmonic surface without solution-phase molecule transfer. In this technique, a polydimethylsiloxane (PDMS) thin film an...

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Bibliographic Details
Published in:Journal of biomedical optics 2014-05, Vol.19 (5), p.050501-050501
Main Authors: Li, Ming, Lu, Jing, Qi, Ji, Zhao, Fusheng, Zeng, Jianbo, Yu, Jorn Chi-Chung, Shih, Wei-Chuan
Format: Article
Language:English
Subjects:
Detection
Dimethylpolysiloxanes
Forensic engineering
Imaging
Molecular Imaging - methods
Multiplexing
Nanostructure
Nanostructures
Nylons
Raman spectroscopy
Silicone resins
Spectrum Analysis, Raman - methods
Stamping
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Summary:We report stamping surface-enhanced Raman spectroscopy (S-SERS) for label-free, multiplexed, molecular sensing and large-area, high-resolution molecular imaging on a flexible, nonplasmonic surface without solution-phase molecule transfer. In this technique, a polydimethylsiloxane (PDMS) thin film and nanoporous gold disk SERS substrate play the roles as molecule carrier and Raman signal enhancer, respectively. After stamping the SERS substrate onto the PDMS film, SERS measurements can be directly taken from the "sandwiched" target molecules. The performance of S-SERS is evaluated by the detection of Rhodamine 6G, urea, and its mixture with acetaminophen, in a physiologically relevant concentration range, along with the corresponding SERS spectroscopic maps. S-SERS features simple sample preparation, low cost, and high reproducibility, which could lead to SERS-based sensing and imaging for point-of-care and forensics applications.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.JBO.19.5.050501